The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse mod...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 22, 2022
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| In: |
JCI insight
Year: 2022, Jahrgang: 7, Heft: 22, Pages: 1-16 |
| ISSN: | 2379-3708 |
| DOI: | 10.1172/jci.insight.153337 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/jci.insight.153337 Verlag, lizenzpflichtig, Volltext: https://insight.jci.org/articles/view/153337 
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| Verfasserangaben: | Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, and Jonathan M. Harnoss |
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| 520 | |a Here, we investigated the importance of PHD1-3 in an azoxymethane- (AOM-) and dextran sodium sulfate-induced (DSS-induced) mouse model of CAC. Moreover, to gain a deeper understanding of the specific role of PHD2 - the key oxygen sensor (25) - in the pathogenesis of CAC, we used transgenic mouse models harboring a tissue-specific deletion of Phd2. We demonstrate that the 3 PHD isoenzymes have distinct, whether promoting (PHD1), diminishing (PHD2), or neutral (PHD3), effects on CAC growth in the AOM/DSS model. | ||
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