Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer
Purpose: The clinical relevance of CA 19-9 as surrogate biomarker in advanced pancreatic cancer is a matter of debate.Experimental Design: This retrospective multicenter study included patients with histologically confirmed advanced pancreatic cancer treated with first-line therapy. Analysis of CA 1...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 February 2010
|
| In: |
Clinical cancer research
Year: 2010, Jahrgang: 16, Heft: 3, Pages: 986-994 |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-09-2205 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-09-2205
|
| Verfasserangaben: | Stefan Boeck, Michael Haas, Rüdiger P. Laubender, Frank Kullmann, Christina Klose, Christiane J. Bruns, Ralf Wilkowski, Petra Stieber, Stefan Holdenrieder, Hannes Buchner, Ulrich Mansmann, and Volker Heinemann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1832493326 | ||
| 003 | DE-627 | ||
| 005 | 20230710161518.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230126s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1158/1078-0432.CCR-09-2205 |2 doi | |
| 035 | |a (DE-627)1832493326 | ||
| 035 | |a (DE-599)KXP1832493326 | ||
| 035 | |a (OCoLC)1389822073 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Böck, Stefan |d 1977- |e VerfasserIn |0 (DE-588)129950580 |0 (DE-627)484977768 |0 (DE-576)297917978 |4 aut | |
| 245 | 1 | 0 | |a Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer |c Stefan Boeck, Michael Haas, Rüdiger P. Laubender, Frank Kullmann, Christina Klose, Christiane J. Bruns, Ralf Wilkowski, Petra Stieber, Stefan Holdenrieder, Hannes Buchner, Ulrich Mansmann, and Volker Heinemann |
| 264 | 1 | |c 1 February 2010 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.01.2023 | ||
| 520 | |a Purpose: The clinical relevance of CA 19-9 as surrogate biomarker in advanced pancreatic cancer is a matter of debate.Experimental Design: This retrospective multicenter study included patients with histologically confirmed advanced pancreatic cancer treated with first-line therapy. Analysis of CA 19-9 was done using the Elecsys assay (Roche Diagnostics). For an analysis of CA 19-9 kinetics, at least three measurements during first-line chemotherapy had to be available. The effect of pretreatment CA 19-9 levels on time-to-progression (TTP) and overall survival (OS) was modeled by Cox proportional hazards regression. The effect of CA 19-9 kinetics was also modeled by Cox proportional hazards regression where CA 19-9 was treated as a time-varying covariate.Results: One hundred and fifteen patients from five German centers were included; 73% of them were treated within prospective clinical trials. Median TTP was 4.4 months and median OS was 9.4 months; univariate analysis indicated that pretreatment CA 19-9 [as continuous variable, log (CA 19-9)] was significantly associated with TTP [hazard ratio (HR), 1.24; P < 0.001] and OS (HR, 1.16; P = 0.002). These associations remained significant within multivariate analysis. For CA 19-9 kinetics during chemotherapy, data from 69 patients (TTP) and 84 patients (OS) were available, respectively; log (CA 19-9) kinetics after start of treatment were found to be a significant predictor for TTP in univariate (HR, 1.48; P < 0.001) and multivariate (HR, 1.45; P < 0.001) analyses, and also for OS (univariate: HR, 1.34; P < 0.001; multivariate: HR, 1.38; P < 0.001).Conclusion: Pretreatment CA 19-9 and CA 19-9 kinetics may serve as a useful serum biomarker in advanced pancreatic cancer. Clin Cancer Res; 16(3); 986-94 | ||
| 700 | 1 | |a Haas, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Laubender, Rüdiger P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kullmann, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klose, Christina |e VerfasserIn |0 (DE-588)1054563640 |0 (DE-627)791610012 |0 (DE-576)410326658 |4 aut | |
| 700 | 1 | |a Bruns, Christiane J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wilkowski, Ralf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stieber, Petra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holdenrieder, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buchner, Hannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mansmann, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heinemann, Volker |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical cancer research |d Philadelphia, Pa. [u.a.] : AACR, 1995 |g 16(2010), 3, Seite 986-994 |h Online-Ressource |w (DE-627)325489971 |w (DE-600)2036787-9 |w (DE-576)094502234 |x 1557-3265 |7 nnas |a Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer |
| 773 | 1 | 8 | |g volume:16 |g year:2010 |g number:3 |g pages:986-994 |g extent:7 |a Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1158/1078-0432.CCR-09-2205 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230126 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1054563640 |a Klose, Christina |m 1054563640:Klose, Christina |p 5 | ||
| 999 | |a KXP-PPN1832493326 |e 4252151244 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 26.01.2023"],"id":{"doi":["10.1158/1078-0432.CCR-09-2205"],"eki":["1832493326"]},"relHost":[{"pubHistory":["1.1995 -"],"title":[{"title":"Clinical cancer research","title_sort":"Clinical cancer research"}],"origin":[{"publisher":"AACR","dateIssuedDisp":"1995-","dateIssuedKey":"1995","publisherPlace":"Philadelphia, Pa. [u.a.]"}],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"American Association for Cancer Research"}],"language":["eng"],"name":{"displayForm":["American Association for Cancer Research"]},"part":{"year":"2010","volume":"16","extent":"7","issue":"3","pages":"986-994","text":"16(2010), 3, Seite 986-994"},"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancerClinical cancer research","recId":"325489971","id":{"eki":["325489971"],"zdb":["2036787-9"],"issn":["1557-3265"]},"note":["Gesehen am 08.06.2023","Fortsetzung der Druck-Ausgabe"]}],"name":{"displayForm":["Stefan Boeck, Michael Haas, Rüdiger P. Laubender, Frank Kullmann, Christina Klose, Christiane J. Bruns, Ralf Wilkowski, Petra Stieber, Stefan Holdenrieder, Hannes Buchner, Ulrich Mansmann, and Volker Heinemann"]},"language":["eng"],"recId":"1832493326","type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"1 February 2010","dateIssuedKey":"2010"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Stefan","family":"Böck","display":"Böck, Stefan"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Michael","family":"Haas","display":"Haas, Michael"},{"display":"Laubender, Rüdiger P.","family":"Laubender","given":"Rüdiger P.","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Kullmann, Frank","family":"Kullmann","roleDisplay":"VerfasserIn","given":"Frank","role":"aut"},{"display":"Klose, Christina","family":"Klose","given":"Christina","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Bruns, Christiane J.","family":"Bruns","given":"Christiane J.","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","given":"Ralf","roleDisplay":"VerfasserIn","display":"Wilkowski, Ralf","family":"Wilkowski"},{"display":"Stieber, Petra","family":"Stieber","role":"aut","given":"Petra","roleDisplay":"VerfasserIn"},{"given":"Stefan","roleDisplay":"VerfasserIn","role":"aut","display":"Holdenrieder, Stefan","family":"Holdenrieder"},{"family":"Buchner","display":"Buchner, Hannes","role":"aut","given":"Hannes","roleDisplay":"VerfasserIn"},{"display":"Mansmann, Ulrich","family":"Mansmann","role":"aut","given":"Ulrich","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Volker","family":"Heinemann","display":"Heinemann, Volker"}],"title":[{"title_sort":"Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer","title":"Application of a time-varying covariate model to the analysis of CA 19-9 as serum biomarker in patients with advanced pancreatic cancer"}],"physDesc":[{"extent":"7 S."}]} | ||
| SRT | |a BOECKSTEFAAPPLICATIO1201 | ||