Impaired in vitro growth response of plasma-treated cardiomyocytes predicts poor outcome in patients with transthyretin amyloidosis

Direct toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulat...

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Hauptverfasser: Hein, Selina (VerfasserIn) , Furkel, Jennifer (VerfasserIn) , Knoll, Maximilian (VerfasserIn) , Siepen, Fabian aus dem (VerfasserIn) , Schönland, Stefan (VerfasserIn) , Hegenbart, Ute (VerfasserIn) , Katus, Hugo (VerfasserIn) , Kristen, Arnt (VerfasserIn) , Konstandin, Mathias (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 22 January 2021
In: Clinical research in cardiology
Year: 2021, Jahrgang: 110, Heft: 4, Pages: 579-590
ISSN:1861-0692
DOI:10.1007/s00392-020-01801-y
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00392-020-01801-y
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Verfasserangaben:Selina Hein, Jennifer Furkel, Maximilian Knoll, Fabian aus dem Siepen, Stefan Schönland, Ute Hegenbart, Hugo A. Katus, Arnt V. Kristen, Mathias H. Konstandin
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Zusammenfassung:Direct toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis.
Beschreibung:Gesehen am 26.01.2023
Beschreibung:Online Resource
ISSN:1861-0692
DOI:10.1007/s00392-020-01801-y