Prediction model for contractile function of circulatory death donor hearts based on microvascular flow shifts during ex situ hypothermic cardioplegic machine perfusion
Background - - Hearts procured from circulatory death donors (DCD) are predominantly maintained by machine perfusion (MP) with normothermic donor blood. Currently, DCD heart function is evaluated by lactate and visual inspection. We have shown that MP with the cardioplegic, crystalloid Custodiol‐N...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 Nov 2022
|
| In: |
Journal of the American Heart Association
Year: 2022, Jahrgang: 11, Heft: 23, Pages: 1-13 |
| ISSN: | 2047-9980 |
| DOI: | 10.1161/JAHA.122.027146 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/JAHA.122.027146 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/JAHA.122.027146 
|
| Verfasserangaben: | Lars Saemann, Matthias Kohl, Gábor Veres, Sevil Korkmaz‐Icöz, Anne Großkopf, Matthias Karck, Andreas Simm, Folker Wenzel, Gábor Szabó |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1832655105 | ||
| 003 | DE-627 | ||
| 005 | 20250112024741.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230130s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1161/JAHA.122.027146 |2 doi | |
| 035 | |a (DE-627)1832655105 | ||
| 035 | |a (DE-599)KXP1832655105 | ||
| 035 | |a (OCoLC)1389536052 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Saemann, Lars |d 1994- |e VerfasserIn |0 (DE-588)1203655118 |0 (DE-627)1688668497 |4 aut | |
| 245 | 1 | 0 | |a Prediction model for contractile function of circulatory death donor hearts based on microvascular flow shifts during ex situ hypothermic cardioplegic machine perfusion |c Lars Saemann, Matthias Kohl, Gábor Veres, Sevil Korkmaz‐Icöz, Anne Großkopf, Matthias Karck, Andreas Simm, Folker Wenzel, Gábor Szabó |
| 264 | 1 | |c 16 Nov 2022 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.01.2023 | ||
| 520 | |a Background - - Hearts procured from circulatory death donors (DCD) are predominantly maintained by machine perfusion (MP) with normothermic donor blood. Currently, DCD heart function is evaluated by lactate and visual inspection. We have shown that MP with the cardioplegic, crystalloid Custodiol‐N solution is superior to blood perfusion to maintain porcine DCD hearts. However, no method has been developed yet to predict the contractility of DCD hearts after cardioplegic MP. We hypothesize that the shift of microvascular flow during continuous MP with a cardioplegic preservation solution predicts the contractility of DCD hearts. - - Methods and Results - - In a pig model, DCD hearts were harvested and maintained by MP with hypothermic, oxygenated Custodiol‐N for 4 hours while myocardial microvascular flow was measured by Laser Doppler Flow (LDF) technology. Subsequently, hearts were perfused with blood for 2 hours, and left ventricular contractility was measured after 30 and 120 minutes. Various novel parameters which represent the LDF shift were computed. We used 2 combined LDF shift parameters to identify bivariate prediction models. Using the new prediction models based on LDF shifts, highest r2 for end‐systolic pressure was 0.77 (P=0.027), for maximal slope of pressure increment was 0.73 (P=0.037), and for maximal slope of pressure decrement was 0.75 (P=0.032) after 30 minutes of reperfusion. After 120 minutes of reperfusion, highest r2 for end‐systolic pressure was 0.81 (P=0.016), for maximal slope of pressure increment was 0.90 (P=0.004), and for maximal slope of pressure decrement was 0.58 (P=0.115). Identical prediction models were identified for maximal slope of pressure increment and for maximal slope of pressure decrement at both time points. Lactate remained constant and therefore was unsuitable for prediction. - - Conclusions - - Contractility of DCD hearts after continuous MP with a cardioplegic preservation solution can be predicted by the shift of LDF during MP. | ||
| 650 | 4 | |a coronary microvasculature | |
| 650 | 4 | |a Custodiol‐N | |
| 650 | 4 | |a donation after circulatory death | |
| 650 | 4 | |a heart transplantation | |
| 650 | 4 | |a machine perfusion | |
| 650 | 4 | |a myocardial microcirculation | |
| 650 | 4 | |a prediction model | |
| 700 | 1 | |8 1\p |a Kohl, Matthias |d 1973- |e VerfasserIn |0 (DE-588)131448293 |0 (DE-627)509449743 |0 (DE-576)298484471 |4 aut | |
| 700 | 1 | |a Veres, Gábor |e VerfasserIn |0 (DE-588)1080537139 |0 (DE-627)844782319 |0 (DE-576)453604927 |4 aut | |
| 700 | 1 | |a Korkmaz-İçöz, Sevil |e VerfasserIn |0 (DE-588)1062748697 |0 (DE-627)806830336 |0 (DE-576)420147845 |4 aut | |
| 700 | 1 | |a Großkopf, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karck, Matthias |d 1961- |e VerfasserIn |0 (DE-588)130833525 |0 (DE-627)505909340 |0 (DE-576)298366169 |4 aut | |
| 700 | 1 | |a Simm, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Wenzel, Folker |d 1970- |e VerfasserIn |0 (DE-588)120100584 |0 (DE-627)08044671X |0 (DE-576)292041837 |4 aut | |
| 700 | 1 | |a Szabó, Gábor |d 1969- |e VerfasserIn |0 (DE-588)1022955152 |0 (DE-627)717338681 |0 (DE-576)366215485 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American Heart Association |t Journal of the American Heart Association |d New York, NY : Association, 2012 |g 11(2022), 23 vom: Nov., Artikel-ID e027146, Seite 1-13 |h Online-Ressource |w (DE-627)688605427 |w (DE-600)2653953-6 |w (DE-576)361844719 |x 2047-9980 |7 nnas |
| 773 | 1 | 8 | |g volume:11 |g year:2022 |g number:23 |g month:11 |g elocationid:e027146 |g pages:1-13 |g extent:13 |a Prediction model for contractile function of circulatory death donor hearts based on microvascular flow shifts during ex situ hypothermic cardioplegic machine perfusion |
| 856 | 4 | 0 | |u https://doi.org/10.1161/JAHA.122.027146 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ahajournals.org/doi/10.1161/JAHA.122.027146 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20230130 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1022955152 |a Szabó, Gábor |m 1022955152:Szabó, Gábor |d 910000 |d 910200 |e 910000PS1022955152 |e 910200PS1022955152 |k 0/910000/ |k 1/910000/910200/ |p 9 |y j | ||
| 998 | |g 130833525 |a Karck, Matthias |m 130833525:Karck, Matthias |d 910000 |d 910200 |e 910000PK130833525 |e 910200PK130833525 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 1062748697 |a Korkmaz-İçöz, Sevil |m 1062748697:Korkmaz-İçöz, Sevil |d 910000 |d 910200 |e 910000PK1062748697 |e 910200PK1062748697 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 1080537139 |a Veres, Gábor |m 1080537139:Veres, Gábor |d 50000 |e 50000PV1080537139 |k 0/50000/ |p 3 | ||
| 998 | |g 1203655118 |a Saemann, Lars |m 1203655118:Saemann, Lars |d 50000 |e 50000PS1203655118 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1832655105 |e 425495848X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Prediction model for contractile function of circulatory death donor hearts based on microvascular flow shifts during ex situ hypothermic cardioplegic machine perfusion","title":"Prediction model for contractile function of circulatory death donor hearts based on microvascular flow shifts during ex situ hypothermic cardioplegic machine perfusion"}],"note":["Gesehen am 30.01.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"origin":[{"publisher":"Association","dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisherPlace":"New York, NY"}],"title":[{"title":"Journal of the American Heart Association","title_sort":"Journal of the American Heart Association","subtitle":"JAHA"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 09.01.14"],"recId":"688605427","physDesc":[{"extent":"Online-Ressource"}],"disp":"American Heart AssociationJournal of the American Heart Association","pubHistory":["1.2012 -"],"titleAlt":[{"title":"Journal of the American Heart Association, Cardiovascular and Cerebrovascular Disease"},{"title":"JAHA"}],"corporate":[{"role":"aut","display":"American Heart Association"}],"id":{"eki":["688605427"],"issn":["2047-9980"],"zdb":["2653953-6"]},"part":{"text":"11(2022), 23 vom: Nov., Artikel-ID e027146, Seite 1-13","extent":"13","issue":"23","pages":"1-13","volume":"11","year":"2022"}}],"person":[{"display":"Saemann, Lars","role":"aut","given":"Lars","family":"Saemann"},{"role":"aut","given":"Matthias","family":"Kohl","display":"Kohl, Matthias"},{"family":"Veres","given":"Gábor","role":"aut","display":"Veres, Gábor"},{"display":"Korkmaz-İçöz, Sevil","family":"Korkmaz-İçöz","given":"Sevil","role":"aut"},{"role":"aut","given":"Anne","family":"Großkopf","display":"Großkopf, Anne"},{"display":"Karck, Matthias","family":"Karck","role":"aut","given":"Matthias"},{"role":"aut","given":"Andreas","family":"Simm","display":"Simm, Andreas"},{"family":"Wenzel","given":"Folker","role":"aut","display":"Wenzel, Folker"},{"display":"Szabó, Gábor","family":"Szabó","given":"Gábor","role":"aut"}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"16 Nov 2022"}],"recId":"1832655105","physDesc":[{"extent":"13 S."}],"id":{"eki":["1832655105"],"doi":["10.1161/JAHA.122.027146"]},"name":{"displayForm":["Lars Saemann, Matthias Kohl, Gábor Veres, Sevil Korkmaz‐Icöz, Anne Großkopf, Matthias Karck, Andreas Simm, Folker Wenzel, Gábor Szabó"]}} | ||
| SRT | |a SAEMANNLARPREDICTION1620 | ||