Lipid droplets lighting up: insights from live microscopy
Lipid droplets emerge as important intracellular organelles relevant for lipid homeostasis and the pathophysiology of metabolic diseases. Here, we present a personal view on the current knowledge about the biogenesis of mammalian cytoplasmic lipid droplets, with a focus on microscopy and especially...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 March 2010
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| In: |
FEBS letters
Year: 2010, Jahrgang: 584, Heft: 11, Pages: 2168-2175 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2010.03.035 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.febslet.2010.03.035 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2010.03.035 
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| Verfasserangaben: | Margarete Digel, Robert Ehehalt, Joachim Füllekrug |
| Zusammenfassung: | Lipid droplets emerge as important intracellular organelles relevant for lipid homeostasis and the pathophysiology of metabolic diseases. Here, we present a personal view on the current knowledge about the biogenesis of mammalian cytoplasmic lipid droplets, with a focus on microscopy and especially live imaging. We also discuss difficulties related to the lipid droplet proteome, contentious views on lipid droplet growth, and last but not least the evidence for the heterogeneity of lipid droplets within a single cell. We conclude with an outline of the most important future challenges. |
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| Beschreibung: | Gesehen am 02.02.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2010.03.035 |