SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs
Protein secretion plays a central role in modulating interactions of the human pathogen Listeria monocytogenes with its environment. Recently, secretion of RNA has emerged as an important strategy used by the pathogen to manipulate the host cell response to its advantage. In general, the Sec-depende...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 November 2022
|
| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 23, Pages: 1-21 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms232315021 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms232315021 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/23/23/15021 
|
| Verfasserangaben: | Lisa Teubner, Renate Frantz, Luigi La Pietra, Martina Hudel, Jasmin Bazant, Günter Lochnit, Lena Eismann, Günter Kramer, Trinad Chakraborty and Mobarak Abu Mraheil |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1833362926 | ||
| 003 | DE-627 | ||
| 005 | 20230706234258.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230207s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms232315021 |2 doi | |
| 035 | |a (DE-627)1833362926 | ||
| 035 | |a (DE-599)KXP1833362926 | ||
| 035 | |a (OCoLC)1389535862 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Teubner, Lisa |e VerfasserIn |0 (DE-588)1242484485 |0 (DE-627)177239338X |4 aut | |
| 245 | 1 | 0 | |a SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs |c Lisa Teubner, Renate Frantz, Luigi La Pietra, Martina Hudel, Jasmin Bazant, Günter Lochnit, Lena Eismann, Günter Kramer, Trinad Chakraborty and Mobarak Abu Mraheil |
| 264 | 1 | |c 30 November 2022 | |
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.02.2022 | ||
| 520 | |a Protein secretion plays a central role in modulating interactions of the human pathogen Listeria monocytogenes with its environment. Recently, secretion of RNA has emerged as an important strategy used by the pathogen to manipulate the host cell response to its advantage. In general, the Sec-dependent translocation pathway is a major route for protein secretion in L. monocytogenes, but mechanistic insights into the secretion of RNA by these pathways are lacking. Apart from the classical SecA1 secretion pathway, L. monocytogenes also encodes for a SecA paralogue (SecA2) which targets the export of a specific subset of proteins, some of which are involved in virulence. Here, we demonstrated that SecA2 co-sediments with translating ribosomes and provided evidence that it associates with a subset of secreted small non-coding RNAs (sRNAs) that induce high levels of IFN-β response in host cells. We found that enolase, which is translocated by a SecA2-dependent mechanism, binds to several sRNAs, suggesting a pathway by which sRNAs are targeted to the supernatant of L. monocytogenes. | ||
| 650 | 4 | |a <i>Listeria monocytogenes</i> | |
| 650 | 4 | |a IFN-beta | |
| 650 | 4 | |a SecA2 | |
| 650 | 4 | |a secreted RNA | |
| 700 | 1 | |a Frantz, Renate |e VerfasserIn |4 aut | |
| 700 | 1 | |a La Pietra, Luigi |e VerfasserIn |0 (DE-588)122271082X |0 (DE-627)1741958601 |4 aut | |
| 700 | 1 | |a Hudel, Martina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bazant, Jasmin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lochnit, Günter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eismann, Lena |e VerfasserIn |0 (DE-588)119295131X |0 (DE-627)1671480872 |4 aut | |
| 700 | 1 | |a Kramer, Günter |e VerfasserIn |0 (DE-588)1060239582 |0 (DE-627)799340294 |0 (DE-576)416341136 |4 aut | |
| 700 | 1 | |a Chakraborty, Trinad |d 1951- |e VerfasserIn |0 (DE-588)1111572038 |0 (DE-627)865642761 |0 (DE-576)476177391 |4 aut | |
| 700 | 1 | |a Abu Mraheil, Mobarak |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 23(2022), 23, Artikel-ID 15021, Seite 1-21 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs |
| 773 | 1 | 8 | |g volume:23 |g year:2022 |g number:23 |g elocationid:15021 |g pages:1-21 |g extent:21 |a SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms232315021 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/23/23/15021 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230207 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1060239582 |a Kramer, Günter |m 1060239582:Kramer, Günter |d 700000 |d 706000 |e 700000PK1060239582 |e 706000PK1060239582 |k 0/700000/ |k 1/700000/706000/ |p 8 | ||
| 998 | |g 119295131X |a Eismann, Lena |m 119295131X:Eismann, Lena |p 7 | ||
| 999 | |a KXP-PPN1833362926 |e 4268047441 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"30 November 2022","dateIssuedKey":"2022"}],"language":["eng"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"2000-","dateIssuedKey":"2000","publisher":"Molecular Diversity Preservation International","publisherPlace":"Basel"}],"language":["eng"],"recId":"316340715","title":[{"title_sort":"International journal of molecular sciences","title":"International journal of molecular sciences"}],"pubHistory":["1.2000 -"],"disp":"SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAsInternational journal of molecular sciences","part":{"pages":"1-21","text":"23(2022), 23, Artikel-ID 15021, Seite 1-21","volume":"23","year":"2022","extent":"21","issue":"23"},"id":{"zdb":["2019364-6"],"issn":["1422-0067","1661-6596"],"eki":["316340715"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"IJMS"}],"note":["Gesehen am 17.09.20"]}],"recId":"1833362926","title":[{"title_sort":"SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs","title":"SecA2 associates with translating ribosomes and contributes to the secretion of potent IFN-β inducing RNAs"}],"person":[{"roleDisplay":"VerfasserIn","family":"Teubner","given":"Lisa","role":"aut","display":"Teubner, Lisa"},{"role":"aut","display":"Frantz, Renate","roleDisplay":"VerfasserIn","family":"Frantz","given":"Renate"},{"roleDisplay":"VerfasserIn","family":"La Pietra","given":"Luigi","role":"aut","display":"La Pietra, Luigi"},{"display":"Hudel, Martina","role":"aut","family":"Hudel","given":"Martina","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Bazant, Jasmin","roleDisplay":"VerfasserIn","given":"Jasmin","family":"Bazant"},{"role":"aut","display":"Lochnit, Günter","roleDisplay":"VerfasserIn","family":"Lochnit","given":"Günter"},{"role":"aut","display":"Eismann, Lena","roleDisplay":"VerfasserIn","given":"Lena","family":"Eismann"},{"role":"aut","display":"Kramer, Günter","roleDisplay":"VerfasserIn","family":"Kramer","given":"Günter"},{"family":"Chakraborty","given":"Trinad","roleDisplay":"VerfasserIn","display":"Chakraborty, Trinad","role":"aut"},{"display":"Abu Mraheil, Mobarak","role":"aut","given":"Mobarak","family":"Abu Mraheil","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"21 S."}],"name":{"displayForm":["Lisa Teubner, Renate Frantz, Luigi La Pietra, Martina Hudel, Jasmin Bazant, Günter Lochnit, Lena Eismann, Günter Kramer, Trinad Chakraborty and Mobarak Abu Mraheil"]},"note":["Gesehen am 07.02.2022"],"id":{"eki":["1833362926"],"doi":["10.3390/ijms232315021"]},"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a TEUBNERLISSECA2ASSOC3020 | ||