Overall response to anti-IL-5/anti-IL5-Rα treatment in severe asthma does not depend on initial bronchodilator responsiveness
Positive bronchodilator responsiveness (BDR) (change in forced expiratory volume in 1 second [ΔFEV1] ≥ +200 mL and ≥ +12%) after inhalation of a short-acting beta-2 agonist has been an inclusion criterion in licensing trials of anti-interleukin 5/anti-interleukin 5 receptor alpha (anti-IL-5/anti-IL-...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 July 2022
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| In: |
The journal of allergy and clinical immunology. In practice
Year: 2022, Jahrgang: 10, Heft: 12, Pages: 3174-3183 |
| ISSN: | 2213-2201 |
| DOI: | 10.1016/j.jaip.2022.07.007 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaip.2022.07.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822007061 
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| Verfasserangaben: | Carlo Mümmler, Hendrik Suhling, Julia Walter, Nikolaus Kneidinger, Roland Buhl, Moritz Z. Kayser, Nora Drick, Jürgen Behr, Tobias Welte, Stephanie Korn, Katrin Milger |
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| 520 | |a Positive bronchodilator responsiveness (BDR) (change in forced expiratory volume in 1 second [ΔFEV1] ≥ +200 mL and ≥ +12%) after inhalation of a short-acting beta-2 agonist has been an inclusion criterion in licensing trials of anti-interleukin 5/anti-interleukin 5 receptor alpha (anti-IL-5/anti-IL-5Rα) biologics in severe asthma. However, in clinical practice, patients with severe uncontrolled asthma frequently show a negative BDR. To investigate whether the response to anti-IL5/anti-IL5Rα therapies differs between patients with positive and negative BDR at baseline. | ||
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