Itching in atopic dermatitis: patient- and physician-reported outcomes in the German Atopic Dermatitis registry TREATgermany
TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Pati...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
Jan 23, 2023
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| In: |
Acta dermato-venereologica
Year: 2023, Volume: 103, Pages: 1-6 |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/actadv.v103.4426 |
| Online Access: | Resolving-System, kostenfrei: https://dx.doi.org/10.2340/actadv.v103.4426
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| Author Notes: | Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schäkel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Brücher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt and the TREATgermany study group |
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| 245 | 1 | 0 | |a Itching in atopic dermatitis |b patient- and physician-reported outcomes in the German Atopic Dermatitis registry TREATgermany |c Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schäkel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Brücher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt and the TREATgermany study group |
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| 520 | |a TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician. | ||
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