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Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [11C] (R)-PK11195 PET (MEMSA-trial)

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The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable w...

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Main Authors: Dodel, Richard C. (Author) , Spottke, Annika (Author) , Gerhard, Alexander (Author) , Reuss, Alexander (Author) , Reinecker, Sylvia (Author) , Schimke, Nicole (Author) , Trenkwalder, Claudia (Author) , Sixel-Döring, Friederike (Author) , Herting, Birgit (Author) , Kamm, Christoph (Author) , Gasser, Thomas (Author) , Sawires, Martin (Author) , Geser, Felix (Author) , Köllensperger, Martin (Author) , Seppi, Klaus (Author) , Kloss, Manja (Author) , Krause, Martin (Author) , Daniels, Christine (Author) , Deuschl, Günther (Author) , Böttger, Silke (Author) , Naumann, Markus (Author) , Lipp, Axel (Author) , Gruber, Doreen (Author) , Kupsch, Andreas (Author) , Du, Yansheng (Author) , Turkheimer, Federico (Author) , Brooks, David J. (Author) , Klockgether, Thomas (Author) , Poewe, Werner (Author) , Wenning, Gregor (Author) , Schade-Brittinger, Carmen (Author) , Oertel, Wolfgang H. (Author) , Eggert, Karla (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Movement disorders
Year: 2010, Volume: 25, Issue: 1, Pages: 97-107
ISSN:1531-8257
DOI:10.1002/mds.22732
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mds.22732
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.22732
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Author Notes:Richard Dodel, Annika Spottke, Alexander Gerhard, Alexander Reuss, Sylvia Reinecker, Nicole Schimke, Claudia Trenkwalder, Friederike Sixel-Döring, Birgit Herting, Christoph Kamm, Thomas Gasser, Martin Sawires, Felix Geser, Martin Köllensperger, Klaus Seppi, Manja Kloss, Martin Krause, Christine Daniels, Günther Deuschl, Silke Böttger, Markus Naumann, Axel Lipp, Doreen Gruber, Andreas Kupsch, Yansheng Du, Federico Turkheimer, David J. Brooks, Thomas Klockgether, Werner Poewe, Gregor Wenning, Carmen Schade-Brittinger, Wolfgang H. Oertel, and Karla Eggert
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Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [11C] (R)-PK11195 PET (MEMSA-trial) by Dodel, Richard C. (Author) , Spottke, Annika (Author) , Gerhard, Alexander (Author) , Reuss, Alexander (Author) , Reinecker, Sylvia (Author) , Schimke, Nicole (Author) , Trenkwalder, Claudia (Author) , Sixel-Döring, Friederike (Author) , Herting, Birgit (Author) , Kamm, Christoph (Author) , Gasser, Thomas (Author) , Sawires, Martin (Author) , Geser, Felix (Author) , Köllensperger, Martin (Author) , Seppi, Klaus (Author) , Kloss, Manja (Author) , Krause, Martin (Author) , Daniels, Christine (Author) , Deuschl, Günther (Author) , Böttger, Silke (Author) , Naumann, Markus (Author) , Lipp, Axel (Author) , Gruber, Doreen (Author) , Kupsch, Andreas (Author) , Du, Yansheng (Author) , Turkheimer, Federico (Author) , Brooks, David J. (Author) , Klockgether, Thomas (Author) , Poewe, Werner (Author) , Wenning, Gregor (Author) , Schade-Brittinger, Carmen (Author) , Oertel, Wolfgang H. (Author) , Eggert, Karla (Author) ,


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