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Stereoselective synthesis of β-proline derivatives from allylamines via domino hydroformylation/Wittig olefination and Aza-Michael addition

Under appropriate reaction conditions, a domino hydroformylation/Wittig olefination can be accomplished with derivatives of allylamines and stabilized Wittig ylides. A further highly diastereoselective aza-Michael reaction yields β-proline derivatives. These are, for example, useful as building bloc...

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Bibliographic Details
Main Authors: Farwick, Andreas (Author) , Helmchen, Günter (Author)
Format: Article (Journal)
Language:English
Published: March 23, 2010
In: Advanced synthesis & catalysis
Year: 2010, Volume: 352, Issue: 6, Pages: 1023-1032
ISSN:1615-4169
DOI:10.1002/adsc.201000016
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/adsc.201000016
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201000016
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Author Notes:Andreas Farwick and Günter Helmchen
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Summary:Under appropriate reaction conditions, a domino hydroformylation/Wittig olefination can be accomplished with derivatives of allylamines and stabilized Wittig ylides. A further highly diastereoselective aza-Michael reaction yields β-proline derivatives. These are, for example, useful as building blocks for alkaloid syntheses.
Item Description:Gesehen am 13.02.2023
Physical Description:Online Resource
ISSN:1615-4169
DOI:10.1002/adsc.201000016

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