Asna1/TRC40-mediated membrane insertion of tail-anchored proteins
Tail-anchored (TA) proteins insert post-translationally into the membrane of the endoplasmic reticulum (ER) and span the membrane by their C-terminal transmembrane domain. We have reconstituted membrane insertion of TA proteins from recombinant Asna1/TA protein complexes and ER-derived membranes. Ou...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 May 2010
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| In: |
Journal of cell science
Year: 2010, Jahrgang: 123, Heft: 9, Pages: 1522-1530 |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.055970 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1242/jcs.055970
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| Verfasserangaben: | Vincenzo Favaloro, Fabio Vilardi, Rainer Schlecht, Matthias P. Mayer and Bernhard Dobberstein |
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| 520 | |a Tail-anchored (TA) proteins insert post-translationally into the membrane of the endoplasmic reticulum (ER) and span the membrane by their C-terminal transmembrane domain. We have reconstituted membrane insertion of TA proteins from recombinant Asna1/TA protein complexes and ER-derived membranes. Our data show that Asna1 can mediate membrane insertion of RAMP4 and Sec61β without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the ER membrane. By contrast, membrane insertion of cytochrome b5 can proceed independently of Asna1 and nucleotides. | ||
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