Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso
Objective To assess the efficacy of methylene blue (MB) monotherapy in semi-immune adults with uncomplicated malaria in Burkina Faso. Methods In an open-label controlled phase II study with 60 semi-immune adults with uncomplicated falciparum malaria in Nouna, north-western Burkina Faso, MB monothera...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 May 2010
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| In: |
Tropical medicine & international health
Year: 2010, Jahrgang: 15, Heft: 6, Pages: 713-717 |
| ISSN: | 1365-3156 |
| DOI: | 10.1111/j.1365-3156.2010.02526.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1365-3156.2010.02526.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-3156.2010.02526.x 
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| Verfasserangaben: | Mamadou Bountogo, Augustin Zoungrana, Boubacar Coulibaly, Christina Klose, Ulrich Mansmann, Frank P. Mockenhaupt, Jürgen Burhenne, Gerd Mikus, Ingeborg Walter-Sack, R. Heiner Schirmer, Ali Sié, Peter Meissner, and Olaf Müller |
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| 245 | 1 | 0 | |a Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria |b a controlled trial in Burkina Faso |c Mamadou Bountogo, Augustin Zoungrana, Boubacar Coulibaly, Christina Klose, Ulrich Mansmann, Frank P. Mockenhaupt, Jürgen Burhenne, Gerd Mikus, Ingeborg Walter-Sack, R. Heiner Schirmer, Ali Sié, Peter Meissner, and Olaf Müller |
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| 520 | |a Objective To assess the efficacy of methylene blue (MB) monotherapy in semi-immune adults with uncomplicated malaria in Burkina Faso. Methods In an open-label controlled phase II study with 60 semi-immune adults with uncomplicated falciparum malaria in Nouna, north-western Burkina Faso, MB monotherapy (390 mg twice daily) was given sequentially to groups of 20 adults for 7 days (MB7), 5 days (MB5) and 3 days (MB3), respectively. The primary outcome was the rate of adequate clinical and parasitological response (ACPR) on day 28 of follow-up. Results Of the study population, 27/58 (47%) and 5/51 (10%) patients still had parasites on days 2 and 3, respectively, of follow-up resulting in 9/58 (16%) early treatment failures. By day 14, no recrudescence was observed but in 4/19 (MB5) and 2/20 (MB3) individuals by day 28. The PCR-corrected rate of ACPR was 72%, 58% and 85% in groups 7, 5 and 3, respectively, by per protocol analysis. Self-limiting dysuria was the most frequent adverse event. Conclusions MB acts slowly against the blood stages of P. falciparum. MB alone needs to be given for at least 7 days to be efficacious in the treatment of falciparum malaria but should be used in combination with a fast acting antimalarial. | ||
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