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Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients

Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous den...

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Hauptverfasser: Domschke, Christoph (VerfasserIn) , Schütz, Florian (VerfasserIn) , Sommerfeldt, Nora (VerfasserIn) , Rom, Joachim (VerfasserIn) , Scharf, Alexander (VerfasserIn) , Sohn, Christof (VerfasserIn) , Schneeweiss, Andreas (VerfasserIn) , Beckhove, Philipp (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: Cancer immunology immunotherapy
Year: 2010, Jahrgang: 59, Heft: 3, Pages: 479-486
ISSN:1432-0851
DOI:10.1007/s00262-009-0801-9
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-009-0801-9
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Verfasserangaben:Christoph Domschke, Florian Schuetz, Nora Sommerfeldt, Joachim Rom, Alexander Scharf, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove
Beschreibung
Zusammenfassung:Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous dendritic cells (DC). In this study, we demonstrate the presence of specific tumor-reactive BM memory T cells in altogether 56 out of 129 primarily operated breast cancer patients by short-term IFN-γ EliSpot assays with unstimulated T cells and tumor antigen presenting, autologous DCs. We observed tumor-reactive BM memory T cells predominantly in patients with primarily metastatic disease (P = 0.011) or with increased concentrations of tumor marker CA 15-3 in the peripheral blood (P = 0.004), respectively. Memory T cell reactivity against HLA-A*0201-restricted peptides from the tumor-associated antigens MUC1, Hpa16-24 and Hpa183-191 was also detected particularly in patients with elevated peripheral CA 15-3 concentrations (P < 0.05). Altogether these data indicate that the systemic presence of tumor-derived antigens promotes an induction of tumor-specific cellular immune responses in the human BM.
Beschreibung:Published online: 2 December 2009
Gesehen am 16.02.2023
Beschreibung:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-009-0801-9

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