Buchumschlag

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation

Proteins with Pumilio RNA binding domains (Puf proteins) are ubiquitous in eukaryotes. Some Puf proteins bind to the 3′-untranslated regions of mRNAs, acting to repress translation and promote degradation; others are involved in ribosomal RNA maturation. The genome of Trypanosoma brucei encodes elev...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Droll, Dorothea (VerfasserIn) , Archer, Stuart K. (VerfasserIn) , Fenn, Katelyn (VerfasserIn) , Delhi, Praveen (VerfasserIn) , Matthews, Keith (VerfasserIn) , Clayton, Christine (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 12 February 2010
In: FEBS letters
Year: 2010, Jahrgang: 584, Heft: 6, Pages: 1156-1162
ISSN:1873-3468
DOI:10.1016/j.febslet.2010.02.018
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.febslet.2010.02.018
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2010.02.018
Volltext
Verfasserangaben:Dorothea Droll, Stuart Archer, Katelyn Fenn, Praveen Delhi, Keith Matthews, Christine Clayton
Beschreibung
Zusammenfassung:Proteins with Pumilio RNA binding domains (Puf proteins) are ubiquitous in eukaryotes. Some Puf proteins bind to the 3′-untranslated regions of mRNAs, acting to repress translation and promote degradation; others are involved in ribosomal RNA maturation. The genome of Trypanosoma brucei encodes eleven Puf proteins whose function cannot be predicted by sequence analysis. We show here that epitope-tagged TbPUF7 is located in the nucleolus, and associated with a nuclear cyclophilin-like protein, TbNCP1. RNAi targeting PUF7 reduced trypanosome growth and inhibited two steps in ribosomal RNA processing.
Beschreibung:Gesehen am 20.02.2023
Beschreibung:Online Resource
ISSN:1873-3468
DOI:10.1016/j.febslet.2010.02.018

Ähnliche Einträge