PNPLA3(I148M) inhibits lipolysis by perilipin-5-dependent competition with ATGL
The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In t...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
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| In: |
Cells
Year: 2023, Jahrgang: 12, Heft: 1, Pages: 1-26 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells12010073 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells12010073 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/12/1/73 
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| Verfasserangaben: | Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth and Beate Katharina Straub |
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| 245 | 1 | 0 | |a PNPLA3(I148M) inhibits lipolysis by perilipin-5-dependent competition with ATGL |c Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth and Beate Katharina Straub |
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| 520 | |a The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In this study, we investigated the mechanistic interaction of PNPLA3 with lipid droplet (LD)-associated proteins of the perilipin family, which serve as gatekeepers for LD degradation. | ||
| 650 | 4 | |a alcoholic steatohepatitis (ASH) | |
| 650 | 4 | |a ballooned hepatocytes | |
| 650 | 4 | |a lipid droplets | |
| 650 | 4 | |a lipoloysis | |
| 650 | 4 | |a NAFLD | |
| 650 | 4 | |a non-alcoholic steatohepatitis (NASH) | |
| 650 | 4 | |a perilipin | |
| 650 | 4 | |a PNPLA3 | |
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| 700 | 1 | |a Hartmann, Nils |e VerfasserIn |4 aut | |
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