O-ring aortic banding versus traditional transverse aortic constriction for modeling pressure overload-induced cardiac hypertrophy
Aortic banding in mice is one of the most commonly used experimental models for cardiac pressure overload-induced cardiac hypertrophy and the induction of heart failure. The previously used technique is based on a threaded suture around the aortic arch tied over a blunted 27 G needle to create steno...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) Video |
| Language: | English |
| Published: |
October 6th, 2022
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| In: |
JoVE. Video journal
Year: 2022, Issue: 188, Pages: 1-12 |
| ISSN: | 1940-087X |
| DOI: | 10.3791/64455 |
| Subjects: | |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3791/64455 Verlag, lizenzpflichtig, Volltext: https://www.jove.com/it/t/64455/o--ring-aortic-banding-versus-traditional-transverse-aortic-constriction-for-modeling-pressure-overload--induced-cardiac-hypertrophy 
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| Author Notes: | Nesrin Schmiedel, Anca Remes, Mohsen Valadan, Susanne Hille, Andrea Matzen, Derk Frank, Norbert Frey, Lorenz Lehmann, Oliver J. Müller |
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| 520 | |a Aortic banding in mice is one of the most commonly used experimental models for cardiac pressure overload-induced cardiac hypertrophy and the induction of heart failure. The previously used technique is based on a threaded suture around the aortic arch tied over a blunted 27 G needle to create stenosis. This method depends on the surgeon manually tightening the thread and, thus, leads to high variance in the diameter size. A newly refined method described by Melleby et al. promises less variance and more reproducibility after surgery. The new technique, o-ring- aortic banding (ORAB), uses a non-slip rubber ring instead of a suture with a thread, resulting in reduced variation in pressure overload and reproducible phenotypes of cardiac hypertrophy. During surgery, the o-ring is placed between the brachiocephalic and left carotid arteries. Successful constriction is confirmed by echocardiography. After 1 day, correct placement of the ring results in an increased flow velocity in the transverse aorta over the o-ring-induced stenosis. After 2 weeks, impaired cardiac function is proven by decreased ejection fraction and increased wall thickness. Importantly, besides less variance in the diameter size, ORAB is associated with lower intra- and post-operative mortality rates compared with transverse aortic constriction (TAC). Thus, ORAB represents a superior method to the commonly used TAC surgery, resulting in more reproducible results and a possible reduction in the number of animals needed. | ||
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