Redox responses in patients with sepsis: high correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels
Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0),...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 Aug 2010
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| In: |
Mediators of inflammation
Year: 2010, Jahrgang: 2010, Pages: 1-8 |
| ISSN: | 1466-1861 |
| DOI: | 10.1155/2010/985614 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2010/985614 Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/mi/2010/985614/ 
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| Verfasserangaben: | Thorsten Brenner, Claudia Rosenhagen, Jochen Steppan, Christoph Lichtenstern, Jürgen Weitz, Thomas Bruckner, Eike O. Martin, Ursula Hoffmann, Markus A. Weigand, and Stefan Hofer |
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| 245 | 1 | 0 | |a Redox responses in patients with sepsis |b high correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels |c Thorsten Brenner, Claudia Rosenhagen, Jochen Steppan, Christoph Lichtenstern, Jürgen Weitz, Thomas Bruckner, Eike O. Martin, Ursula Hoffmann, Markus A. Weigand, and Stefan Hofer |
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| 520 | |a Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers ( ) were collected once; samples from postoperative patients ( ) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: : ). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response. | ||
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