Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of periphera...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05/24/2010
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| In: |
Nano letters
Year: 2010, Jahrgang: 10, Heft: 7, Pages: 2318-2322 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/nl101019s |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl101019s
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| Verfasserangaben: | Wolfgang Eck, Anthony I. Nicholson, Hanswalter Zentgraf, Wolfhard Semmler, and Sönke Bartling |
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| 520 | |a Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent. | ||
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