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Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera): part II, biomimetic potential and applications

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In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matri...

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Hauptverfasser: Ehrlich, Hermann (VerfasserIn) , Steck, Eric (VerfasserIn) , Ilan, M. (VerfasserIn) , Maldonado, M. (VerfasserIn) , Muricy, G. (VerfasserIn) , Bavestrello, G. (VerfasserIn) , Kljajic, Z. (VerfasserIn) , Carballo, J. L. (VerfasserIn) , Schiaparelli, S. (VerfasserIn) , Ereskovsky, A. (VerfasserIn) , Schupp, P. (VerfasserIn) , Born, R. (VerfasserIn) , Worch, H. (VerfasserIn) , Bazhenov, V. V. (VerfasserIn) , Kurek, D. (VerfasserIn) , Varlamov, V. (VerfasserIn) , Vyalikh, D. (VerfasserIn) , Kummer, K. (VerfasserIn) , Sivkov, V. V. (VerfasserIn) , Molodtsov, S. L. (VerfasserIn) , Meissner, H. (VerfasserIn) , Richter, G. (VerfasserIn) , Hunoldt, S. (VerfasserIn) , Kammer, M. (VerfasserIn) , Paasch, S. (VerfasserIn) , Krasokhin, V. (VerfasserIn) , Patzke, G. (VerfasserIn) , Brunner, E. (VerfasserIn) , Richter, Wiltrud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 May 2010
In: International journal of biological macromolecules
Year: 2010, Jahrgang: 47, Heft: 2, Pages: 141-145
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2010.05.009
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijbiomac.2010.05.009
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0141813010001637
Volltext
Verfasserangaben:H. Ehrlich, E. Steck, M. Ilan, M. Maldonado, G. Muricy, G. Bavestrello, Z. Kljajic, J.L. Carballo, S. Schiaparelli, A. Ereskovsky, P. Schupp, R. Born, H. Worch, V.V. Bazhenov, D. Kurek, V. Varlamov, D. Vyalikh, K. Kummer, V.V. Sivkov, S.L. Molodtsov, H. Meissner, G. Richter, S. Hunoldt, M. Kammer, S. Paasch, V. Krasokhin, G. Patzke, E. Brunner, W. Richter
Beschreibung
Zusammenfassung:In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matrix similar to that found in other cartilage tissue engineering constructs. Chitin scaffolds also supported deposition of a proteoglycan-rich extracellular matrix of chondrocytes seeded bioconstructs in an in vivo environment. We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts.
Beschreibung:Gesehen am 02.03.2023
Beschreibung:Online Resource
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2010.05.009

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