High prevalence of amyloid in 150 surgically removed heart valves - a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions
Introduction - The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet. - Methods - One hundred fifty surgically resected heart valve specimens [67.4±1.0 years; aortic stenosis (AS), n=100; aortic regurgitation, n=19; mitral stenosis, n=7;...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 June 2009
|
| In: |
Cardiovascular pathology
Year: 2010, Volume: 19, Issue: 4, Pages: 228-235 |
| ISSN: | 1879-1336 |
| DOI: | 10.1016/j.carpath.2009.04.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.carpath.2009.04.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1054880709000350 
|
| Author Notes: | Arnt V. Kristen, Philipp A. Schnabel, Bettina Winter, Burkhard M. Helmke, Thomas Longerich, Stefan Hardt, Achim Koch, Falk-Udo Sack, Hugo A. Katus, Reinhold P. Linke, Thomas J. Dengler |
| Summary: | Introduction - The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet. - Methods - One hundred fifty surgically resected heart valve specimens [67.4±1.0 years; aortic stenosis (AS), n=100; aortic regurgitation, n=19; mitral stenosis, n=7; mitral regurgitation, n=24] were qualitatively, semiquantitatively, and immunohistochemically analyzed and correlated with clinical data. - Results - Amyloid was found in 83/150 specimens with highest prevalence in AS (74/100), intermediate prevalence in mitral stenosis (2/7) and regurgitation (7/24), and lowest prevalence in aortic regurgitation (2/19). Severe and polymorphic amyloid deposits were almost exclusively found in AS (35/100). Filamentous cloudy amyloid patterns occurred with the same frequency in AS (29/100). A combination of both was found only in AS (n=7/100). By immunohistochemistry, none of the most common amyloid proteins was identified except for a weak staining by the apolipoprotein AI antibody, but more intense adjacent to amyloid deposits. Amyloid correlated with valvular thickening (P<.05), hyperlipidemia (P=.07), coronary artery disease (P=.084), and obesity (P=.082). - Conclusions - Localized valvular amyloid is predominantly found in stenotic aortic valves. It appears to depend on atheroinflammatory conditions and high shear-stress hemodynamics. Further studies are needed to identify the underlying protein. |
|---|---|
| Item Description: | Gesehen am 03.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1336 |
| DOI: | 10.1016/j.carpath.2009.04.005 |