Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam
Midazolam metabolic clearance to 1′-hydroxymidazolam is an accurate measure of CYP3A activity which requires extensive plasma and urine sampling. The objective of this study was to find a new limited sampling strategy (LSS) to predict midazolam metabolic clearance to 1′-hydroxymidazolam and subseque...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 August 2010
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| In: |
European journal of clinical pharmacology
Year: 2010, Jahrgang: 66, Heft: 11, Pages: 1137-1141 |
| ISSN: | 1432-1041 |
| DOI: | 10.1007/s00228-010-0878-2 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00228-010-0878-2 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00228-010-0878-2 
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| Verfasserangaben: | Stephanie Katzenmaier, Christoph Markert, Gerd Mikus |
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| 520 | |a Midazolam metabolic clearance to 1′-hydroxymidazolam is an accurate measure of CYP3A activity which requires extensive plasma and urine sampling. The objective of this study was to find a new limited sampling strategy (LSS) to predict midazolam metabolic clearance to 1′-hydroxymidazolam and subsequently CYP3A activity in an easy and reliable way, reducing costs and labour. | ||
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