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Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam

Midazolam metabolic clearance to 1′-hydroxymidazolam is an accurate measure of CYP3A activity which requires extensive plasma and urine sampling. The objective of this study was to find a new limited sampling strategy (LSS) to predict midazolam metabolic clearance to 1′-hydroxymidazolam and subseque...

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Hauptverfasser: Katzenmaier, Stephanie Katharina (VerfasserIn) , Markert, Christoph (VerfasserIn) , Mikus, Gerd (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 August 2010
In: European journal of clinical pharmacology
Year: 2010, Jahrgang: 66, Heft: 11, Pages: 1137-1141
ISSN:1432-1041
DOI:10.1007/s00228-010-0878-2
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00228-010-0878-2
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00228-010-0878-2
Volltext
Verfasserangaben:Stephanie Katzenmaier, Christoph Markert, Gerd Mikus
Beschreibung
Zusammenfassung:Midazolam metabolic clearance to 1′-hydroxymidazolam is an accurate measure of CYP3A activity which requires extensive plasma and urine sampling. The objective of this study was to find a new limited sampling strategy (LSS) to predict midazolam metabolic clearance to 1′-hydroxymidazolam and subsequently CYP3A activity in an easy and reliable way, reducing costs and labour.
Beschreibung:Gesehen am 08.03.2023
Beschreibung:Online Resource
ISSN:1432-1041
DOI:10.1007/s00228-010-0878-2

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