A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli
The chemotaxis system of Escherichia coli is sensitive to small relative changes in ambient chemoattractant concentrations over a broad range. Interactions among receptors are crucial to this sensitivity, as is precise adaptation, the return of chemoreceptor activity to prestimulus levels in a const...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 20, 2010
|
| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2010, Volume: 107, Issue: 40, Pages: 17170-17175 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.1005017107 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1005017107 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/doi/full/10.1073/pnas.1005017107 
|
| Author Notes: | Clinton H. Hansen, Victor Sourjik, and Ned S. Wingreen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 183855470X | ||
| 003 | DE-627 | ||
| 005 | 20230710153424.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230308s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.1005017107 |2 doi | |
| 035 | |a (DE-627)183855470X | ||
| 035 | |a (DE-599)KXP183855470X | ||
| 035 | |a (OCoLC)1389820970 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Hansen, Clinton H. |e VerfasserIn |0 (DE-588)128176292X |0 (DE-627)1837632723 |4 aut | |
| 245 | 1 | 2 | |a A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli |c Clinton H. Hansen, Victor Sourjik, and Ned S. Wingreen |
| 264 | 1 | |c September 20, 2010 | |
| 300 | |b Illustrationen | ||
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.03.2023 | ||
| 520 | |a The chemotaxis system of Escherichia coli is sensitive to small relative changes in ambient chemoattractant concentrations over a broad range. Interactions among receptors are crucial to this sensitivity, as is precise adaptation, the return of chemoreceptor activity to prestimulus levels in a constant chemoeffector environment through methylation and demethylation of receptors. Signal integration and cooperativity have been attributed to strongly coupled, mixed teams of receptors, but receptors become individually methylated according to their ligand occupancy states. Here, we present a model of dynamic signaling teams that reconciles strong coupling among receptors with receptor-specific methylation. Receptor trimers of dimers couple to form a honeycomb lattice, consistent with cryo-electron microscopy (cryoEM) tomography, within which the boundaries of signaling teams change rapidly. Our model helps explain the inferred increase in signaling team size with receptor modification, and indicates that active trimers couple more s0999 Alle Personen wegen Universitätsbibliographie Heidelberg bitte stehen lassen! HDHB/08.03.2023 | ||
| 700 | 1 | |a Sourjik, Victor |d 1970- |e VerfasserIn |0 (DE-588)1020549998 |0 (DE-627)69125737X |0 (DE-576)360687725 |4 aut | |
| 700 | 1 | |a Wingreen, Ned |e VerfasserIn |0 (DE-588)1163765244 |0 (DE-627)1028126956 |0 (DE-576)508207347 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a National Academy of Sciences (Washington, DC) |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : National Acad. of Sciences, 1915 |g 107(2010), 40, Seite 17170-17175 |h Online-Ressource |w (DE-627)254235379 |w (DE-600)1461794-8 |w (DE-576)073260509 |x 1091-6490 |7 nnas |
| 773 | 1 | 8 | |g volume:107 |g year:2010 |g number:40 |g pages:17170-17175 |g extent:6 |a A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli |
| 856 | 4 | 0 | |u https://doi.org/10.1073/pnas.1005017107 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.pnas.org/doi/full/10.1073/pnas.1005017107 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230308 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1020549998 |a Sourjik, Victor |m 1020549998:Sourjik, Victor |d 700000 |d 706000 |e 700000PS1020549998 |e 706000PS1020549998 |k 0/700000/ |k 1/700000/706000/ |p 2 | ||
| 999 | |a KXP-PPN183855470X |e 428463688X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"id":{"issn":["1091-6490"],"zdb":["1461794-8"],"eki":["254235379"]},"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"1915-","dateIssuedKey":"1915","publisher":"National Acad. of Sciences"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Proceedings of the National Academy of Sciences of the United States of America","title":"Proceedings of the National Academy of Sciences of the United States of America"}],"language":["eng"],"corporate":[{"display":"National Academy of Sciences","roleDisplay":"VerfasserIn","role":"aut"}],"recId":"254235379","disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","note":["Gesehen am 09.03.2022"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"extent":"6","text":"107(2010), 40, Seite 17170-17175","volume":"107","pages":"17170-17175","issue":"40","year":"2010"},"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}],"pubHistory":["1.1915 -"]}],"physDesc":[{"extent":"6 S.","noteIll":"Illustrationen"}],"name":{"displayForm":["Clinton H. Hansen, Victor Sourjik, and Ned S. Wingreen"]},"id":{"doi":["10.1073/pnas.1005017107"],"eki":["183855470X"]},"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"September 20, 2010"}],"recId":"183855470X","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.03.2023"],"person":[{"given":"Clinton H.","family":"Hansen","role":"aut","roleDisplay":"VerfasserIn","display":"Hansen, Clinton H."},{"given":"Victor","family":"Sourjik","role":"aut","display":"Sourjik, Victor","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Wingreen, Ned","roleDisplay":"VerfasserIn","given":"Ned","family":"Wingreen"}],"title":[{"title_sort":"dynamic-signaling-team model for chemotaxis receptors in Escherichia coli","title":"A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli"}]} | ||
| SRT | |a HANSENCLINDYNAMICSIG2020 | ||