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Is fetal hydrops in turner syndrome a risk factor for the development of maternal mirror syndrome?

Mirror syndrome is a rare and serious maternal condition associated with immune and non-immune fetal hydrops after 16 weeks of gestational age. Subjacent conditions associated with fetal hydrops may carry different risks for Mirror syndrome. Fetuses with Turner syndrome are frequently found to be hy...

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Main Authors: Bedei, Ivonne (Author) , Graf, Alexander (Author) , Gloning, Karl-Philipp (Author) , Meyer-Wittkopf, Matthias (Author) , Willner, Daria (Author) , Krapp, Martin (Author) , Hentze, Sabine (Author) , Scharf, Alexander (Author) , Degenhardt, Jan (Author) , Heling, Kai-Sven (Author) , Kozlowski, Peter (Author) , Trautmann, Kathrin (Author) , Jahns, Kai (Author) , Geipel, Anne (Author) , Tekesin, Ismail (Author) , Elsässer, Michael (Author) , Wilhelm, Lucas (Author) , Gottschalk, Ingo (Author) , Baumüller, Jan-Erik (Author) , Birdir, Cahit (Author) , Zöllner, Felix (Author) , Wolter, Aline (Author) , Schenk, Johanna (Author) , Gehrke, Tascha (Author) , Keil, Corinna (Author) , Espinosa, Jimmy (Author) , Axt-Fliedner, Roland (Author)
Format: Article (Journal)
Language:English
Published: 5 August 202
In: Journal of Clinical Medicine
Year: 2022, Volume: 11, Issue: 15, Pages: 1-8
ISSN:2077-0383
DOI:10.3390/jcm11154588
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm11154588
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/11/15/4588
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Author Notes:Ivonne Alexandra Bedei, Alexander Graf, Karl-Philipp Gloning, Matthias Meyer-Wittkopf, Daria Willner, Martin Krapp, Sabine Hentze, Alexander Scharf, Jan Degenhardt, Kai-Sven Heling, Peter Kozlowski, Kathrin Trautmann, Kai Jahns, Anne Geipel, Ismail Tekesin, Michael Elsässer, Lucas Wilhelm, Ingo Gottschalk, Jan-Erik Baumüller, Cahit Birdir, Felix Zöllner, Aline Wolter, Johanna Schenk, Tascha Gehrke, Corinna Keil, Jimmy Espinosa and Roland Axt-Fliedner
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Summary:Mirror syndrome is a rare and serious maternal condition associated with immune and non-immune fetal hydrops after 16 weeks of gestational age. Subjacent conditions associated with fetal hydrops may carry different risks for Mirror syndrome. Fetuses with Turner syndrome are frequently found to be hydropic on ultrasound. We designed a retrospective multicenter study to evaluate the risk for Mirror syndrome among pregnancies complicated with Turner syndrome and fetal hydrops. Data were extracted from a questionnaire sent to specialists in maternal fetal medicine in Germany. Out of 758 cases, 138 fulfilled our inclusion criteria and were included in the analysis. Of the included 138, 66 presented with persisting hydrops at or after 16 weeks. The frequency of placental hydrops/placentomegaly was rather low (8.1%). Of note, no Mirror syndrome was observed in our study cohort. We propose that the risk of this pregnancy complication varies according to the subjacent cause of fetal hydrops. In Turner syndrome, the risk for Mirror syndrome is lower than that reported in the literature. Our observations are relevant for clinical management and parental counseling.
Item Description:Gesehen am 10.03.2023
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm11154588

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