High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission
Background: We sought to determine the diagnostic performance of the new high-sensitivity cardiac troponin T (hs-cTnT) assay for early detection of non-ST-segment myocardial infarction (NSTEMI) in patients with acute coronary syndrome.Methods: We enrolled patients with retrospectively confirmed unst...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 19, 2010
|
| In: |
Clinical chemistry
Year: 2010, Jahrgang: 56, Heft: 4, Pages: 642-650 |
| ISSN: | 1530-8561 |
| DOI: | 10.1373/clinchem.2009.134460 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1373/clinchem.2009.134460
|
| Verfasserangaben: | Evangelos Giannitsis, Meike Becker, Kerstin Kurz, Georg Hess, Dietmar Zdunek, and Hugo A Katus |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 183885603X | ||
| 003 | DE-627 | ||
| 005 | 20230710152330.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230310s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1373/clinchem.2009.134460 |2 doi | |
| 035 | |a (DE-627)183885603X | ||
| 035 | |a (DE-599)KXP183885603X | ||
| 035 | |a (OCoLC)1389820926 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Giannitsis, Evangelos |e VerfasserIn |0 (DE-588)113336241 |0 (DE-627)577184091 |0 (DE-576)289759579 |4 aut | |
| 245 | 1 | 0 | |a High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission |c Evangelos Giannitsis, Meike Becker, Kerstin Kurz, Georg Hess, Dietmar Zdunek, and Hugo A Katus |
| 264 | 1 | |c January 19, 2010 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.03.2023 | ||
| 520 | |a Background: We sought to determine the diagnostic performance of the new high-sensitivity cardiac troponin T (hs-cTnT) assay for early detection of non-ST-segment myocardial infarction (NSTEMI) in patients with acute coronary syndrome.Methods: We enrolled patients with retrospectively confirmed unstable angina or NSTEMI and an initially negative cTnT concentration and compared the performance of baseline concentrations and serial changes in concentration within 3 and 6 h. Percentage change criteria included ≥20% δ change and ROC-optimized value.Results: Based on the standard fourth-generation cTnT result of ≥0.03 μg/L, an evolving NSTEMI was diagnosed in 26 patients, and 31 patients were classified as having unstable angina. With the use of the hs-cTnT assay at the 99th-percentile cutoff, the percentage of NSTEMI cases detected increased gradually from 61.5% on presentation to 100% within 6 h, and the overall number of MI diagnoses increased by 34.6% (35 vs 26 cases). A δ change ≥20% or ≥ROC-optimized value of >117% within 3 h or ≥243% within 6 h yielded a specificity of 100% at sensitivities between 69% and 76%. The standard cTnT at the 99th percentile was less sensitive than hs-cTnT for early diagnosis of MI on presentation, and follow-up samples obtained within the initial 3 h demonstrated very low specificity of cTnT compared with hs-cTnT.Conclusions: The high-sensitivity cTnT assay increases the number of NSTEMI diagnoses and enables earlier detection of evolving NSTEMI. A doubling of the hs-cTnT concentration within 3 h in the presence of a second concentration ≥99th percentile is associated with a positive predictive value of 100% and a negative predictive value of 88%. | ||
| 700 | 1 | |a Becker, Meike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kurzhals, Kerstin |e VerfasserIn |0 (DE-588)1252718896 |0 (DE-627)1794182632 |4 aut | |
| 700 | 1 | |a Hess, Georg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zdunek, Dietmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical chemistry |d Washington, DC : American Association for Clinical Chemistry, 1955 |g 56(2010), 4, Seite 642-650 |h Online-Ressource |w (DE-627)266883117 |w (DE-600)1468161-4 |w (DE-576)075146401 |x 1530-8561 |7 nnas |a High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission |
| 773 | 1 | 8 | |g volume:56 |g year:2010 |g number:4 |g pages:642-650 |g extent:9 |a High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission |
| 856 | 4 | 0 | |u https://doi.org/10.1373/clinchem.2009.134460 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230310 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 6 |y j | ||
| 998 | |g 113336241 |a Giannitsis, Evangelos |m 113336241:Giannitsis, Evangelos |d 910000 |d 910100 |d 50000 |e 910000PG113336241 |e 910100PG113336241 |e 50000PG113336241 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN183885603X |e 4286923495 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"id":{"issn":["1530-8561"],"eki":["266883117"],"zdb":["1468161-4"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"journal of the American Association for Clinical Chemistry ; international journal of laboratory medicine and molecular diagnostics","title":"Clinical chemistry","title_sort":"Clinical chemistry"}],"origin":[{"dateIssuedKey":"1955","publisherPlace":"Washington, DC ; Oxford","publisher":"American Association for Clinical Chemistry ; Oxford University Press","dateIssuedDisp":"1955-"}],"recId":"266883117","corporate":[{"display":"American Association of Clinical Chemists","role":"isb"}],"disp":"High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admissionClinical chemistry","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"56","year":"2010","text":"56(2010), 4, Seite 642-650","issue":"4","pages":"642-650","extent":"9"},"language":["eng"],"pubHistory":["1.1955 -"],"note":["Gesehen am 26.08.2021"]}],"origin":[{"dateIssuedDisp":"January 19, 2010","dateIssuedKey":"2010"}],"title":[{"title":"High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission","title_sort":"High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1373/clinchem.2009.134460"],"eki":["183885603X"]},"recId":"183885603X","person":[{"given":"Evangelos","display":"Giannitsis, Evangelos","family":"Giannitsis","role":"aut"},{"display":"Becker, Meike","given":"Meike","family":"Becker","role":"aut"},{"family":"Kurzhals","role":"aut","given":"Kerstin","display":"Kurzhals, Kerstin"},{"family":"Hess","role":"aut","display":"Hess, Georg","given":"Georg"},{"family":"Zdunek","role":"aut","given":"Dietmar","display":"Zdunek, Dietmar"},{"family":"Katus","role":"aut","given":"Hugo","display":"Katus, Hugo"}],"note":["Gesehen am 10.03.2023"],"name":{"displayForm":["Evangelos Giannitsis, Meike Becker, Kerstin Kurz, Georg Hess, Dietmar Zdunek, and Hugo A Katus"]},"language":["eng"]} | ||
| SRT | |a GIANNITSISHIGHSENSIT1920 | ||