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The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response

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The anti-inflammatory and antiapoptotic heme degrading enzyme heme oxygenase-1 (HO-1) has been shown recently to interfere with replication of hepatitis C virus (HCV). We investigated the effect of HO-1 products carbon monoxide (CO), iron and biliverdin on HCV replication using the replicon cell lin...

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Main Authors: Lehmann, Elisabeth (Author) , El-Tantawy, Walid Hamdy (Author) , Ocker, Matthias (Author) , Bartenschlager, Ralf (Author) , Lohmann, Volker (Author) , Hashemolhosseini, Said (Author) , Tiegs, Gisa (Author) , Sass, Gabriele (Author)
Format: Article (Journal)
Language:English
Published: 25 January 2010
In: Hepatology
Year: 2010, Volume: 51, Issue: 2, Pages: 398-404
ISSN:1527-3350
DOI:10.1002/hep.23339
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/hep.23339
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.23339
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Author Notes:Elisabeth Lehmann, Walid Hamdy El-Tantawy, Matthias Ocker, Ralf Bartenschlager, Volker Lohmann, Said Hashemolhosseini, Gisa Tiegs, and Gabriele Sass
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A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo by Heuss, Christian (Author) , Rothhaar, Paul (Author) , Burm, Rani (Author) , Lee, Ji Young (Author) , Ralfs, Philipp (Author) , Haselmann, Uta (Author) , Ströh, Luisa J. (Author) , Colasanti, Ombretta (Author) , Tran, Cong Si (Author) , Schäfer, Noemi (Author) , Schnitzler, Paul (Author) , Merle, Uta (Author) , Bartenschlager, Ralf (Author) , Patel, Arvind H. (Author) , Graw, Frederik (Author) , Krey, Thomas (Author) , Laketa, Vibor (Author) , Meuleman, Philip (Author) , Lohmann, Volker (Author) ,


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