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An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen

To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo...

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Bibliographic Details
Main Authors: Lemke, Andreas (Author) , Laun, Frederik B. (Author) , Simon, Dirk (Author) , Stieltjes, Bram (Author) , Schad, Lothar R. (Author)
Format: Article (Journal)
Language:English
Published: 27 July 2010
In: Magnetic resonance in medicine
Year: 2010, Volume: 64, Issue: 6, Pages: 1580-1585
ISSN:1522-2594
DOI:10.1002/mrm.22565
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mrm.22565
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.22565
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Author Notes:Andreas Lemke, Frederik B. Laun, Dirk Simon, Bram Stieltjes, and Lothar R. Schad

MARC

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520 |a To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo times (TE = 50, 70, and 100 msec). The perfusion fraction f and the diffusion coefficient D were extracted from the measured DW-data using the original Intra Voxel Incoherent Motion-equation and a modified version of this equation incorporating relaxation effects. First, the perfusion fraction f in the blood suppressed pancreatic tissue decreased significantly (P = 0.03), whereas the diffusion coefficient D did not change with suppression (P = 0.43). Second, the perfusion fraction f increased significantly with increasing echo time (P = 0.0025), whereas the relaxation time compensated perfusion fraction f′ showed no significant dependence on TE (P = 0.31). These results verify a vascular contribution to the diffusion weighted imaging measurement at low b values and support the Intra Voxel Incoherent Motion-theory. 
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