Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells
Glioblastoma cells with stem-like properties control brain tumour growth and recurrence. Here, we show that endogenous neural precursor cells perform an anti-tumour response by specifically targeting stem-like brain tumour cells. In vitro, neural precursor cells predominantly express bone morphogene...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 30, 2010
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| In: |
Brain
Year: 2010, Jahrgang: 133, Heft: Pt 7, Pages: 1961-1972 |
| ISSN: | 1460-2156 |
| DOI: | 10.1093/brain/awq128 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/brain/awq128
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| Verfasserangaben: | Sridhar Reddy Chirasani, Alexander Sternjak, Peter Wend, Stefan Momma, Benito Campos, Ilaria M. Herrmann, Daniel Graf, Thimios Mitsiadis, Christel Herold-Mende, Daniel Besser, Michael Synowitz, Helmut Kettenmann and Rainer Glass |
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| 245 | 1 | 0 | |a Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells |c Sridhar Reddy Chirasani, Alexander Sternjak, Peter Wend, Stefan Momma, Benito Campos, Ilaria M. Herrmann, Daniel Graf, Thimios Mitsiadis, Christel Herold-Mende, Daniel Besser, Michael Synowitz, Helmut Kettenmann and Rainer Glass |
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| 520 | |a Glioblastoma cells with stem-like properties control brain tumour growth and recurrence. Here, we show that endogenous neural precursor cells perform an anti-tumour response by specifically targeting stem-like brain tumour cells. In vitro, neural precursor cells predominantly express bone morphogenetic protein-7; bone morphogenetic protein-7 is constitutively released from neurospheres and induces canonical bone morphogenetic protein signalling in stem-like glioblastoma cells. Exposure of human and murine stem-like brain tumour cells to neurosphere-derived bone morphogenetic protein-7 induces tumour stem cell differentiation, attenuates stem-like marker expression and reduces self-renewal and the ability for tumour initiation. Neurosphere-derived or recombinant bone morphogenetic protein-7 reduces glioblastoma expansion from stem-like cells by down-regulating the transcription factor Olig2. In vivo, large numbers of bone morphogenetic protein-7-expressing neural precursors encircle brain tumours in young mice, induce canonical bone morphogenetic protein signalling in stem-like glioblastoma cells and can thereby attenuate tumour formation. This anti-tumour response is strongly reduced in older mice. Our results indicate that endogenous neural precursor cells protect the young brain from glioblastoma by releasing bone morphogenetic protein-7, which acts as a paracrine tumour suppressor that represses proliferation, self-renewal and tumour-initiation of stem-like glioblastoma cells. | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Bone Morphogenetic Protein 7 | |
| 650 | 4 | |a Brain Neoplasms | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mice, Inbred C57BL | |
| 650 | 4 | |a Mice, Inbred NOD | |
| 650 | 4 | |a Mice, SCID | |
| 650 | 4 | |a Neoplastic Stem Cells | |
| 650 | 4 | |a Neurons | |
| 650 | 4 | |a Stem Cells | |
| 650 | 4 | |a Tumor Cells, Cultured | |
| 700 | 1 | |a Sternjak, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wend, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Momma, Stefan |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Graf, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mitsiadis, Thimios |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Besser, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Synowitz, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kettenmann, Helmut |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glass, Rainer |e VerfasserIn |4 aut | |
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