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A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation

Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3+DR+-Tregs among the total CD4+CD127low+/−CD25+-Treg cell pool is critically involved in preterm labor induction and kidney transplant...

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Hauptverfasser: Kisielewicz, Anna (VerfasserIn) , Schaier, Matthias (VerfasserIn) , Schmitt, Edgar (VerfasserIn) , Hug, Friederike (VerfasserIn) , Hänsch, Gertrud Maria (VerfasserIn) , Meuer, Stefan (VerfasserIn) , Zeier, Martin (VerfasserIn) , Sohn, Christof (VerfasserIn) , Steinborn-Kröhl, Andrea (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 6 September 2010
In: Clinical immunology
Year: 2010, Jahrgang: 137, Heft: 2, Pages: 209-220
ISSN:1521-7035
DOI:10.1016/j.clim.2010.07.008
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clim.2010.07.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1521661610006741
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Verfasserangaben:Anna Kisielewicz, Matthias Schaier, Edgar Schmitt, Friederike Hug, Gertrud M. Haensch, Stefan Meuer, Martin Zeier, Christof Sohn, Andrea Steinborn
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Zusammenfassung:Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3+DR+-Tregs among the total CD4+CD127low+/−CD25+-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3+DR+-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4+CD127low+/−CD25+-Treg cell pool. Our findings propose that the FoxP3+DR+-Treg subset may be decisively responsible for the suppressive activity of the total CD4+CD127low+/−CD25+-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation.
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Beschreibung:Online Resource
ISSN:1521-7035
DOI:10.1016/j.clim.2010.07.008

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