A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation
Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3+DR+-Tregs among the total CD4+CD127low+/−CD25+-Treg cell pool is critically involved in preterm labor induction and kidney transplant...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 September 2010
|
| In: |
Clinical immunology
Year: 2010, Jahrgang: 137, Heft: 2, Pages: 209-220 |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2010.07.008 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clim.2010.07.008 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1521661610006741 
|
| Verfasserangaben: | Anna Kisielewicz, Matthias Schaier, Edgar Schmitt, Friederike Hug, Gertrud M. Haensch, Stefan Meuer, Martin Zeier, Christof Sohn, Andrea Steinborn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1839092858 | ||
| 003 | DE-627 | ||
| 005 | 20230710151710.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230314s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clim.2010.07.008 |2 doi | |
| 035 | |a (DE-627)1839092858 | ||
| 035 | |a (DE-599)KXP1839092858 | ||
| 035 | |a (OCoLC)1389807987 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kisielewicz, Anna |d 1983- |e VerfasserIn |0 (DE-588)1025475216 |0 (DE-627)722365365 |0 (DE-576)370383818 |4 aut | |
| 245 | 1 | 2 | |a A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation |c Anna Kisielewicz, Matthias Schaier, Edgar Schmitt, Friederike Hug, Gertrud M. Haensch, Stefan Meuer, Martin Zeier, Christof Sohn, Andrea Steinborn |
| 264 | 1 | |c 6 September 2010 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel erscheint das Zeichen + hochgestellt | ||
| 500 | |a Gesehen am 14.03.2023 | ||
| 520 | |a Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3+DR+-Tregs among the total CD4+CD127low+/−CD25+-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3+DR+-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4+CD127low+/−CD25+-Treg cell pool. Our findings propose that the FoxP3+DR+-Treg subset may be decisively responsible for the suppressive activity of the total CD4+CD127low+/−CD25+-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation. | ||
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Preterm labor | |
| 650 | 4 | |a Regulatory T cells | |
| 650 | 4 | |a Renal transplantation | |
| 650 | 4 | |a Tolerance induction | |
| 650 | 4 | |a Transplant rejection | |
| 700 | 1 | |a Schaier, Matthias |d 1975- |e VerfasserIn |0 (DE-588)129029009 |0 (DE-627)387780335 |0 (DE-576)297455788 |4 aut | |
| 700 | 1 | |a Schmitt, Edgar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hug, Friederike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hänsch, Gertrud Maria |e VerfasserIn |0 (DE-588)1032383380 |0 (DE-627)738394076 |0 (DE-576)323810926 |4 aut | |
| 700 | 1 | |a Meuer, Stefan |d 1951- |e VerfasserIn |0 (DE-588)1020440198 |0 (DE-627)691221286 |0 (DE-576)360422454 |4 aut | |
| 700 | 1 | |a Zeier, Martin |e VerfasserIn |0 (DE-588)1026480302 |0 (DE-627)726772356 |0 (DE-576)371826438 |4 aut | |
| 700 | 1 | |a Sohn, Christof |d 1961- |e VerfasserIn |0 (DE-588)131349287 |0 (DE-627)507642902 |0 (DE-576)298422255 |4 aut | |
| 700 | 1 | |a Steinborn-Kröhl, Andrea |e VerfasserIn |0 (DE-588)1130893448 |0 (DE-627)885250087 |0 (DE-576)48767491X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical immunology |d San Diego, Calif. : Elsevier, 1999 |g 137(2010), 2 vom: Nov., Seite 209-220 |h Online-Ressource |w (DE-627)254637566 |w (DE-600)1462862-4 |w (DE-576)104193654 |x 1521-7035 |7 nnas |a A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation |
| 773 | 1 | 8 | |g volume:137 |g year:2010 |g number:2 |g month:11 |g pages:209-220 |g extent:12 |a A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.clim.2010.07.008 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1521661610006741 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230314 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1130893448 |a Steinborn-Kröhl, Andrea |m 1130893448:Steinborn-Kröhl, Andrea |d 910000 |d 910400 |e 910000PS1130893448 |e 910400PS1130893448 |k 0/910000/ |k 1/910000/910400/ |p 9 |y j | ||
| 998 | |g 131349287 |a Sohn, Christof |m 131349287:Sohn, Christof |d 910000 |d 910400 |e 910000PS131349287 |e 910400PS131349287 |k 0/910000/ |k 1/910000/910400/ |p 8 | ||
| 998 | |g 1026480302 |a Zeier, Martin |m 1026480302:Zeier, Martin |d 50000 |d 910000 |d 910100 |e 50000PZ1026480302 |e 910000PZ1026480302 |e 910100PZ1026480302 |k 0/50000/ |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1020440198 |a Meuer, Stefan |m 1020440198:Meuer, Stefan |d 910000 |d 911600 |d 50000 |e 910000PM1020440198 |e 911600PM1020440198 |e 50000PM1020440198 |k 0/910000/ |k 1/910000/911600/ |k 0/50000/ |p 6 | ||
| 998 | |g 1032383380 |a Hänsch, Gertrud Maria |m 1032383380:Hänsch, Gertrud Maria |d 910000 |d 911600 |d 50000 |e 910000PH1032383380 |e 911600PH1032383380 |e 50000PH1032383380 |k 0/910000/ |k 1/910000/911600/ |k 0/50000/ |p 5 | ||
| 998 | |g 129029009 |a Schaier, Matthias |m 129029009:Schaier, Matthias |d 50000 |e 50000PS129029009 |k 0/50000/ |p 2 | ||
| 998 | |g 1025475216 |a Kisielewicz, Anna |m 1025475216:Kisielewicz, Anna |d 50000 |e 50000PK1025475216 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1839092858 |e 4289383246 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Im Titel erscheint das Zeichen + hochgestellt","Gesehen am 14.03.2023"],"person":[{"display":"Kisielewicz, Anna","family":"Kisielewicz","role":"aut","given":"Anna"},{"given":"Matthias","role":"aut","family":"Schaier","display":"Schaier, Matthias"},{"given":"Edgar","display":"Schmitt, Edgar","family":"Schmitt","role":"aut"},{"given":"Friederike","role":"aut","family":"Hug","display":"Hug, Friederike"},{"role":"aut","family":"Hänsch","display":"Hänsch, Gertrud Maria","given":"Gertrud Maria"},{"given":"Stefan","display":"Meuer, Stefan","family":"Meuer","role":"aut"},{"display":"Zeier, Martin","family":"Zeier","role":"aut","given":"Martin"},{"family":"Sohn","role":"aut","display":"Sohn, Christof","given":"Christof"},{"given":"Andrea","family":"Steinborn-Kröhl","role":"aut","display":"Steinborn-Kröhl, Andrea"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1839092858"],"doi":["10.1016/j.clim.2010.07.008"]},"recId":"1839092858","name":{"displayForm":["Anna Kisielewicz, Matthias Schaier, Edgar Schmitt, Friederike Hug, Gertrud M. Haensch, Stefan Meuer, Martin Zeier, Christof Sohn, Andrea Steinborn"]},"origin":[{"dateIssuedDisp":"6 September 2010","dateIssuedKey":"2010"}],"relHost":[{"title":[{"title_sort":"Clinical immunology","title":"Clinical immunology"}],"pubHistory":["90.1999 -"],"note":["Gesehen am 04.02.20"],"id":{"zdb":["1462862-4"],"eki":["254637566"],"issn":["1521-7035"]},"origin":[{"publisher":"Elsevier ; Academic Press","dateIssuedDisp":"1999-","dateIssuedKey":"1999","publisherPlace":"San Diego, Calif. ; Orlando, Fla."}],"corporate":[{"role":"isb","display":"Clinical Immunology Society"}],"disp":"A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantationClinical immunology","physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"137","text":"137(2010), 2 vom: Nov., Seite 209-220","extent":"12","issue":"2","pages":"209-220","year":"2010"},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"254637566","name":{"displayForm":["Clinical Immunology Society"]}}],"title":[{"title":"A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation","title_sort":"distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation"}],"physDesc":[{"extent":"12 S."}]} | ||
| SRT | |a KISIELEWICDISTINCTSU6201 | ||