Peroxisome Proliferator-Activated Receptor (PPAR)γ can inhibit chronic renal allograft damage

Chronic inflammation and fibrosis are the leading causes of chronic allograft failure. The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor known to have antidiabetogenic and immune effects, and PPARγ forms obligate heterodimers with the retinoid X recept...

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Main Authors: Kiss, Eva (Author) , Popovic, Zoran V. (Author) , Bedke, Jens (Author) , Adams, Judith (Author) , Bonrouhi, Mahnaz (Author) , Babelova, Andrea (Author) , Schmidt, Claudia (Author) , Edenhofer, Frank (Author) , Zschiedrich, Inka C. (Author) , Domhan, Sophie (Author) , Abdollahi, Amir (Author) , Schäfer, Liliana (Author) , Gretz, Norbert (Author) , Porubský, Štefan (Author) , Gröne, Hermann-Josef (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2010
In: The American journal of pathology
Year: 2010, Volume: 176, Issue: 5, Pages: 2150-2162
ISSN:1525-2191
DOI:10.2353/ajpath.2010.090370
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.2353/ajpath.2010.090370
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0002944010600120
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Author Notes:Eva Kiss, Zoran V. Popovic, Jens Bedke, Judith Adams, Mahnaz Bonrouhi, Andrea Babelova, Claudia Schmidt, Frank Edenhofer, Inka Zschiedrich, Sophie Domhan, Amir Abdollahi, Liliana Schäfer, Norbert Gretz, Stefan Porubsky, and Hermann-Josef Gröne
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Summary:Chronic inflammation and fibrosis are the leading causes of chronic allograft failure. The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor known to have antidiabetogenic and immune effects, and PPARγ forms obligate heterodimers with the retinoid X receptor (RXR). We have reported that a retinoic acid (RAR)/RXR-agonist can potently influence the course of renal chronic allograft dysfunction.
Item Description:Gesehen am 14.03.2023
Physical Description:Online Resource
ISSN:1525-2191
DOI:10.2353/ajpath.2010.090370