Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice
The 5-HT4 receptor is a new potential target for antidepressant treatment and may be implicated in the pathogenesis of depression. This study investigated differences in 5-HT4 receptor and 5-HT transporter (5-HTT) binding by quantitative autoradiography of [3H]SB207145 and (S)-[N-methyl-3H]citalopra...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2010
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| In: |
Neurochemistry international
Year: 2010, Jahrgang: 56, Heft: 4, Pages: 603-610 |
| ISSN: | 1872-9754 |
| DOI: | 10.1016/j.neuint.2010.01.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuint.2010.01.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197018610000215 
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| Verfasserangaben: | Cecilie L. Licht, Lisbeth Kirkegaard, Maha Zueger, Sabine Chourbaji, Peter Gass, Susana Aznar, Gitte M. Knudsen |
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| 245 | 1 | 0 | |a Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice |c Cecilie L. Licht, Lisbeth Kirkegaard, Maha Zueger, Sabine Chourbaji, Peter Gass, Susana Aznar, Gitte M. Knudsen |
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| 520 | |a The 5-HT4 receptor is a new potential target for antidepressant treatment and may be implicated in the pathogenesis of depression. This study investigated differences in 5-HT4 receptor and 5-HT transporter (5-HTT) binding by quantitative autoradiography of [3H]SB207145 and (S)-[N-methyl-3H]citalopram in two murine models of depression-related states, olfactory bulbectomy and glucocorticoid receptor heterozygous (GR+/−) mice. The olfactory bulbectomy model is characterized by 5-HT system changes, while the GR+/− mice have a deficit in hypothalamic-pituitary-adrenal (HPA) system control. The olfactory bulbectomized mice displayed increased activity in the open field test, a characteristic depression-like feature of this model. After bulbectomy, 5-HT4 receptor binding was increased in the ventral hippocampus (12%) but unchanged in the dorsal hippocampus, frontal and caudal caudate putamen. Among post hoc analyzed regions, there was a 14% decrease in 5-HT4 receptor binding in the olfactory tubercles. The 5-HTT binding was unchanged in the hippocampus and caudate putamen of bulbectomized mice but post hoc analysis showed small decreases in lateral septum and lateral globus pallidus. In comparison, GR+/− mice had increased 5-HT4 receptor (11%) binding in the caudal caudate putamen and decreased 5-HTT binding in the frontal caudate putamen but no changes in dorsal and ventral hippocampus. Post hoc analysis showed increased 5-HT4 receptor binding in the olfactory tubercles of GR+/− mice. In conclusion, we have found brain regional changes in 5-HT4 receptor and 5-HTT transporter binding in two murine models of depression-related states, characterized by 5-HT and HPA system changes. | ||
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Hippocampus | |
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| 650 | 4 | |a Serotonin 4 receptor | |
| 650 | 4 | |a Serotonin transporter | |
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| 700 | 1 | |a Zueger, Maha |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Knudsen, Gitte M. |e VerfasserIn |4 aut | |
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