CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients
Background: This is the first prospective case-control study that evaluates the expression of tumour-specific antigens on circulating microparticles (MP) in breast cancer patients and in women with benign breast tumour. Materials and Methods: MP were determined by flow cytometry in patients with bre...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 30, 2010
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| In: |
Anticancer research
Year: 2010, Jahrgang: 30, Heft: 5, Pages: 1707-1712 |
| ISSN: | 1791-7530 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/30/5/1707
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| Verfasserangaben: | Susanne Liebhardt, Nina Ditsch, Rienk Nieuwland, Andreas Rank, Udo Jeschke, Franz Von Koch, Klaus Friese and Bettina Toth |
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| 520 | |a Background: This is the first prospective case-control study that evaluates the expression of tumour-specific antigens on circulating microparticles (MP) in breast cancer patients and in women with benign breast tumour. Materials and Methods: MP were determined by flow cytometry in patients with breast cancer (n=34; T1 (n=19) and T2 (n=15)) and women with benign breast tumour (n=19). Results: Patients with lymph node metastases (N1, n=9) showed significantly higher numbers of annexin V+ MP (p=0.042), CD66+ MP (p=0.045), BCRP1+ MP (breast cancer resistance protein) (p=0.025) and Hsp27+ MP (p=0.034) than controls. Furthermore, T1 patients had significantly higher levels of annexin V+ MP (p=0.004), CD66+ MP (p=0.025), BCRP1+ MP (p=0.008) and Hsp27+ MP (p=0.02) than controls. Conclusion: Significant differences are present between breast cancer patients with lymph node metastases and controls concerning annexin V-, CD66-, BCRP1- and Hsp27-positive MP. To specify the role of these MP subpopulations in breast cancer progression, further studies enrolling larger patient groups are part of ongoing research. | ||
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