Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour
This study assessed the outcomes of patients with a gastrointestinal stromal tumour (GIST) that ruptured before or during resection.The records of 23 patients (8 women, 15 men; median age 54 years) with ruptured primary non-metastatic GIST were retrieved from a database of 554 patients. The written...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[December 2010]
|
| In: |
The British journal of surgery
Year: 2010, Jahrgang: 97, Heft: 12, Pages: 1854-1859 |
| ISSN: | 1365-2168 |
| DOI: | 10.1002/bjs.7222 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/bjs.7222
|
| Verfasserangaben: | P. Hohenberger, U. Ronellenfitsch, O. Oladeji, D. Pink, P. Ströbel, E. Wardelmann and P. Reichardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1839124849 | ||
| 003 | DE-627 | ||
| 005 | 20230710151152.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230314s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/bjs.7222 |2 doi | |
| 035 | |a (DE-627)1839124849 | ||
| 035 | |a (DE-599)KXP1839124849 | ||
| 035 | |a (OCoLC)1389807355 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hohenberger, Peter |d 1953- |e VerfasserIn |0 (DE-588)1025311469 |0 (DE-627)72202875X |0 (DE-576)370195574 |4 aut | |
| 245 | 1 | 0 | |a Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour |c P. Hohenberger, U. Ronellenfitsch, O. Oladeji, D. Pink, P. Ströbel, E. Wardelmann and P. Reichardt |
| 264 | 1 | |c [December 2010] | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published: 20 August 2010 | ||
| 500 | |a Gesehen am 14.03.2023 | ||
| 520 | |a This study assessed the outcomes of patients with a gastrointestinal stromal tumour (GIST) that ruptured before or during resection.The records of 23 patients (8 women, 15 men; median age 54 years) with ruptured primary non-metastatic GIST were retrieved from a database of 554 patients. The written surgical and pathology reports were analysed. Review pathology was performed in all 23 cases, and mutational analysis of KIT and platelet-derived growth factor α (PDGFRA) genes was performed in 21 patients. Median follow-up was 52 months.Tumour rupture was spontaneous in 16 patients, following abdominal trauma in two and occurred during resection in five. Primary tumour location was the stomach in six patients, duodenum in one and small bowel in 16. Mean tumour size was 10·2 (range 4-28) cm. According to the Miettinen and Lasota risk classification, the distribution of very low-, low-, intermediate- and high-risk cases was one, two, five and 15 respectively. One patient remained disease-free at 83 months. Fifteen of 16 patients who did not receive adjuvant therapy developed tumour recurrence after a median of 19 months. Median recurrence-free survival in patients with KIT mutations involving codons 557-558 was 11 months.Patients with a rupture of GIST into the abdominal cavity have a risk of recurrence of nearly 100 per cent. In patients with deletion mutations involving codons 557-558, recurrence-free survival was less than 1 year. All patient groups are clear candidates for adjuvant drug therapy. | ||
| 700 | 1 | |a Ronellenfitsch, Ulrich |d 1977- |e VerfasserIn |0 (DE-588)13178322X |0 (DE-627)513952179 |0 (DE-576)29874144X |4 aut | |
| 700 | 1 | |a Oladeji, O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pink, Daniel |d 1973- |e VerfasserIn |0 (DE-588)122616952 |0 (DE-627)082050309 |0 (DE-576)293349975 |4 aut | |
| 700 | 1 | |a Ströbel, Philipp |d 1969- |e VerfasserIn |0 (DE-588)115588272 |0 (DE-627)077346734 |0 (DE-576)289964784 |4 aut | |
| 700 | 1 | |a Wardelmann, Eva |d 1964- |e VerfasserIn |0 (DE-588)121391175 |0 (DE-627)081277458 |0 (DE-576)292686145 |4 aut | |
| 700 | 1 | |a Reichardt, Peter |d 1969- |e VerfasserIn |0 (DE-588)138132313 |0 (DE-627)599720859 |0 (DE-576)162683928 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The British journal of surgery |d Oxford : Oxford University Press, 1913 |g 97(2010), 12 vom: Dez., Seite 1854-1859 |h Online-Ressource |w (DE-627)320453170 |w (DE-600)2006309-X |w (DE-576)091140366 |x 1365-2168 |7 nnas |a Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour |
| 773 | 1 | 8 | |g volume:97 |g year:2010 |g number:12 |g month:12 |g pages:1854-1859 |g extent:6 |a Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour |
| 856 | 4 | 0 | |u https://doi.org/10.1002/bjs.7222 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230314 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 115588272 |a Ströbel, Philipp |m 115588272:Ströbel, Philipp |d 60000 |d 63400 |e 60000PS115588272 |e 63400PS115588272 |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 13178322X |a Ronellenfitsch, Ulrich |m 13178322X:Ronellenfitsch, Ulrich |d 60000 |d 61800 |e 60000PR13178322X |e 61800PR13178322X |k 0/60000/ |k 1/60000/61800/ |p 2 | ||
| 998 | |g 1025311469 |a Hohenberger, Peter |m 1025311469:Hohenberger, Peter |d 60000 |d 61800 |e 60000PH1025311469 |e 61800PH1025311469 |k 0/60000/ |k 1/60000/61800/ |p 1 |x j | ||
| 999 | |a KXP-PPN1839124849 |e 4289747892 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"id":{"doi":["10.1002/bjs.7222"],"eki":["1839124849"]},"language":["eng"],"recId":"1839124849","person":[{"given":"Peter","role":"aut","family":"Hohenberger","display":"Hohenberger, Peter","roleDisplay":"VerfasserIn"},{"display":"Ronellenfitsch, Ulrich","family":"Ronellenfitsch","roleDisplay":"VerfasserIn","given":"Ulrich","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Oladeji, O.","family":"Oladeji","role":"aut","given":"O."},{"display":"Pink, Daniel","family":"Pink","roleDisplay":"VerfasserIn","given":"Daniel","role":"aut"},{"family":"Ströbel","display":"Ströbel, Philipp","roleDisplay":"VerfasserIn","given":"Philipp","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Wardelmann, Eva","family":"Wardelmann","role":"aut","given":"Eva"},{"family":"Reichardt","display":"Reichardt, Peter","roleDisplay":"VerfasserIn","given":"Peter","role":"aut"}],"title":[{"title_sort":"Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour","title":"Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour"}],"note":["Published: 20 August 2010","Gesehen am 14.03.2023"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"[December 2010]","dateIssuedKey":"2010"}],"relHost":[{"part":{"volume":"97","pages":"1854-1859","year":"2010","text":"97(2010), 12 vom: Dez., Seite 1854-1859","extent":"6","issue":"12"},"origin":[{"dateIssuedDisp":"1913-","publisher":"Oxford University Press ; Blackwell Science ; Wiley","publisherPlace":"Oxford ; Oxford ; New York, NY [u.a.]","dateIssuedKey":"1913"}],"disp":"Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumourThe British journal of surgery","pubHistory":["1.1913 -"],"note":["Gesehen am 27.04.2022"],"title":[{"subtitle":"BJS","title":"The British journal of surgery","title_sort":"British journal of surgery"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"id":{"issn":["1365-2168"],"zdb":["2006309-X"],"eki":["320453170"],"doi":["10.1002/(ISSN)1365-2168"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"320453170","titleAlt":[{"title":"BJS"}]}],"name":{"displayForm":["P. Hohenberger, U. Ronellenfitsch, O. Oladeji, D. Pink, P. Ströbel, E. Wardelmann and P. Reichardt"]}} | ||
| SRT | |a HOHENBERGEPATTERNOFR2010 | ||