Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes
Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 November 2022
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| In: |
Molecular metabolism
Year: 2022, Jahrgang: 66, Pages: 1-13 |
| ISSN: | 2212-8778 |
| DOI: | 10.1016/j.molmet.2022.101644 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmet.2022.101644 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2212877822002137 
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| Verfasserangaben: | Ruiyue Qiu, Kristina Alikhanyan, Nadine Volk, Oriana Marques, Christina Mertens, Anand Ruban Agarvas, Sanjana Singh, Rainer Pepperkok, Sandro Altamura, Martina U. Muckenthaler |
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| 520 | |a Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and is a central organ for T2DM. Here, we investigate how the control of iron metabolism in hepatocytes is affected by T2DM. | ||
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| 650 | 4 | |a Iron overload | |
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