Deferoxamine, the newly developed iron chelator LK-614 and N-α-acetyl-histidine in myocardial protection
During cold storage of donor hearts, reactive oxygen species produced by intracellular redox-active chelatable iron potentially alter myocardial function. To reduce this cold-induced injury we investigated the efficacy of two new modifications of the well established histidine-tryptophan-ketoglutera...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 February 2010
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| In: |
Interactive cardiovascular and thoracic surgery
Year: 2010, Volume: 10, Issue: 2, Pages: 181-184 |
| ISSN: | 1569-9285 |
| DOI: | 10.1510/icvts.2009.213280 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1510/icvts.2009.213280 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/icvts/article/10/2/181/644455 
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| Author Notes: | Achim Koch, Sivakkanan Loganathan, Tamas Radovits, Falk-Udo Sack, Matthias Karck, Gabor B. Szabó |
| Summary: | During cold storage of donor hearts, reactive oxygen species produced by intracellular redox-active chelatable iron potentially alter myocardial function. To reduce this cold-induced injury we investigated the efficacy of two new modifications of the well established histidine-tryptophan-ketogluterate (HTK) solution (Custodiol®) with the addition of N-α-acetyl-l-histidine and iron-chelators in a heterotopic rat heart transplantation model. The donor hearts were cardioplegically arrested with 20 ml cardioplegia and stored for 1 h. Then the hearts were anastomosed to the abdominal aorta and vena cava of the recipient (n=30). After 1 h reperfusion, myocardial function and energy charge potential were measured in three groups: HTK-1: addition of l-arginine and N-α-acetyl-l-histidine; HTK-2: addition of iron-chelators deferoxamine and LK-614; traditional HTK - control. After 1 h reperfusion, left ventricular systolic pressure (106±33 vs. 60±39, vs. 67±8 mmHg, P<0.05) and dP/dt minimal (-1388±627 vs. -660±446, vs. 871±188 mmHg/s, P<0.05) were significantly higher in the HTK-1 group. Energy charge potentials were not significantly different. This study showed that the novel modified HTK-1 solution improves myocardial contractility and relaxation after heart transplantation. Nevertheless, addition of the iron-chelators deferoxamine and LK-614 diminished these beneficial effects. |
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| Item Description: | Gesehen am 15.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1569-9285 |
| DOI: | 10.1510/icvts.2009.213280 |