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Impact of drug transporters on cellular resistance towards saquinavir and darunavir

Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We...

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Bibliographische Detailangaben
Hauptverfasser: König, Sonja Katharina (VerfasserIn) , Herzog, Melanie (VerfasserIn) , Theile, Dirk (VerfasserIn) , Zembruski, Nadine Cécile Luise (VerfasserIn) , Haefeli, Walter E. (VerfasserIn) , Weiß, Johanna (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 September 2010
In: The journal of antimicrobial chemotherapy
Year: 2010, Jahrgang: 65, Heft: 11, Pages: 2319-2328
ISSN:1460-2091
DOI:10.1093/jac/dkq324
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/jac/dkq324
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jac/article/65/11/2319/763783
Volltext
Verfasserangaben:Sonja Katharina König, Melanie Herzog, Dirk Theile, Nadine Zembruski, Walter Emil Haefeli and Johanna Weiss
Beschreibung
Zusammenfassung:Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We therefore investigated the effect of saquinavir and darunavir on drug transporter expression and functional consequences for cellular resistance towards these compounds.
Beschreibung:Gesehen am 16.03.2023
Beschreibung:Online Resource
ISSN:1460-2091
DOI:10.1093/jac/dkq324

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