Impact of drug transporters on cellular resistance towards saquinavir and darunavir
Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 September 2010
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| In: |
The journal of antimicrobial chemotherapy
Year: 2010, Jahrgang: 65, Heft: 11, Pages: 2319-2328 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/dkq324 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/jac/dkq324 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jac/article/65/11/2319/763783 
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| Verfasserangaben: | Sonja Katharina König, Melanie Herzog, Dirk Theile, Nadine Zembruski, Walter Emil Haefeli and Johanna Weiss |
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| 520 | |a Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We therefore investigated the effect of saquinavir and darunavir on drug transporter expression and functional consequences for cellular resistance towards these compounds. | ||
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