Enantioselective one-pot rhodium-catalyzed cycloisomerization-Wittig sequence to chiral functionalized 4-alkyl 3-alkylidene tetrahydrofuran(on)es
Alkyl and (hetero)aryl alkyne allyl alcohols can readily be transformed into chiral 4-alkyl 3-alkylidene tetrahydrofurans and tetrahydrofuranones bearing α,β-unsaturated carbonyl side chains in a one-pot fashion via an enantioselective rhodium-catalyzed cycloisomerization-Wittig olefination sequenc...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08. Februar 2010
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| In: |
Synlett
Year: 2010, Heft: 05, Pages: 782-786 |
| ISSN: | 1437-2096 |
| DOI: | 10.1055/s-0029-1219362 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1055/s-0029-1219362 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0029-1219362 |
| Verfasserangaben: | Nadine Körber, Frank Rominger, Thomas J.J. Müller |
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| 520 | |a Alkyl and (hetero)aryl alkyne allyl alcohols can readily be transformed into chiral 4-alkyl 3-alkylidene tetrahydrofurans and tetrahydrofuranones bearing α,β-unsaturated carbonyl side chains in a one-pot fashion via an enantioselective rhodium-catalyzed cycloisomerization-Wittig olefination sequence in good yields (54-86%). | ||
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