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Risk factor analysis for pneumococcal meningitis in adults with invasive pneumococcal infection

Pneumococcal meningitis is a subgroup of invasive pneumococcal disease with a case-fatality rate of up to 30% and long-term sequelae in more than 50% of cases in adults in developed countries. We aimed to determine risk factors for this particular form of pneumococcal disease. We conducted a prospec...

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Bibliographische Detailangaben
Hauptverfasser: Burckhardt, Irene (VerfasserIn) , Burckhardt, F. (VerfasserIn) , Linden, Mark van der (VerfasserIn) , Heeg, Corinna (VerfasserIn) , Reinert, R. R. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 22 January 2010
In: Epidemiology and infection
Year: 2010, Jahrgang: 138, Heft: 9, Pages: 1353-1358
ISSN:1469-4409
DOI:10.1017/S0950268809991683
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0950268809991683
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/risk-factor-analysis-for-pneumococcal-meningitis-in-adults-with-invasive-pneumococcal-infection/5736E9C51FD3B7A91B896A688F2F155A
Volltext
Verfasserangaben:I. Burckhardt, F. Burckhardt, M. Van Der Linden, C. Heeg and R.R. Reinert
Beschreibung
Zusammenfassung:Pneumococcal meningitis is a subgroup of invasive pneumococcal disease with a case-fatality rate of up to 30% and long-term sequelae in more than 50% of cases in adults in developed countries. We aimed to determine risk factors for this particular form of pneumococcal disease. We conducted a prospective population-based laboratory study of invasive pneumococcal disease in adults in North-Rhine-Westphalia, Germany from February 2001 to August 2006. All isolates underwent serotyping and susceptibility testing at the National Reference Centre for Streptococci in Aachen, Germany. Data were analysed using multiple linear regression. A total of 1043 isolates from bacteraemia and 131 isolates from meningitis were included into the study. Serotype 23F and being female were independent risk factors for pneumococcal meningitis. Being ⩾60 years and serotype 1 were associated with a reduced odds ratio. Season, penicillin and macrolide resistance were not statistically associated with CNS involvement.
Beschreibung:Gesehen am 16.03.2023
Beschreibung:Online Resource
ISSN:1469-4409
DOI:10.1017/S0950268809991683

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