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Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients

DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permits parallel and highly sensitive assessment of multiple 5-mC biomarkers. Here, we performed...

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Main Authors: Janke, Florian (Author) , Angeles, Arlou Kristina J. (Author) , Riediger, Anja Lisa (Author) , Bauer, Simone (Author) , Reck, Martin (Author) , Stenzinger, Albrecht (Author) , Schneider, Marc (Author) , Muley, Thomas (Author) , Thomas, Michael (Author) , Christopoulos, Petros (Author) , Sültmann, Holger (Author)
Format: Article (Journal)
Language:English
Published: 02 December 2022
In: Clinical epigenetics
Year: 2022, Volume: 14, Pages: 1-15
ISSN:1868-7083
DOI:10.1186/s13148-022-01387-4
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-022-01387-4
Verlag, kostenfrei, Volltext: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01387-4
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Author Notes:Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos and Holger Sültmann
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Summary:DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permits parallel and highly sensitive assessment of multiple 5-mC biomarkers. Here, we performed genome-wide 5-mC profiling in the plasma of metastatic ALK-rearranged non-small cell lung cancer (NSCLC) patients receiving tyrosine kinase inhibitor therapy. We established a strategy to identify ALK-specific 5-mC changes from cfDNA and demonstrated the suitability of the identified markers for cancer detection, prognosis, and therapy monitoring.
Item Description:Gesehen am 16.11.2023
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-022-01387-4

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