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Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients

DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permits parallel and highly sensitive assessment of multiple 5-mC biomarkers. Here, we performed...

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Bibliographische Detailangaben
Hauptverfasser: Janke, Florian (VerfasserIn) , Angeles, Arlou Kristina J. (VerfasserIn) , Riediger, Anja Lisa (VerfasserIn) , Bauer, Simone (VerfasserIn) , Reck, Martin (VerfasserIn) , Stenzinger, Albrecht (VerfasserIn) , Schneider, Marc (VerfasserIn) , Muley, Thomas (VerfasserIn) , Thomas, Michael (VerfasserIn) , Christopoulos, Petros (VerfasserIn) , Sültmann, Holger (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 December 2022
In: Clinical epigenetics
Year: 2022, Jahrgang: 14, Pages: 1-15
ISSN:1868-7083
DOI:10.1186/s13148-022-01387-4
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-022-01387-4
Verlag, kostenfrei, Volltext: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01387-4
Volltext
Verfasserangaben:Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos and Holger Sültmann
Beschreibung
Zusammenfassung:DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permits parallel and highly sensitive assessment of multiple 5-mC biomarkers. Here, we performed genome-wide 5-mC profiling in the plasma of metastatic ALK-rearranged non-small cell lung cancer (NSCLC) patients receiving tyrosine kinase inhibitor therapy. We established a strategy to identify ALK-specific 5-mC changes from cfDNA and demonstrated the suitability of the identified markers for cancer detection, prognosis, and therapy monitoring.
Beschreibung:Gesehen am 16.11.2023
Beschreibung:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-022-01387-4

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