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Induction of long-lasting regulatory B lymphocytes by modified immune cells in kidney transplant recipients

In previous work, the authors demonstrated that kidney transplant recipients developed donor-specific unresponsiveness when they were given a pretransplant infusion of modified donor-derived PBMCs. In this study, they provide evidence that the immunosuppressive properties of these cells persist and...

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Main Authors: Morath, Christian (Author) , Schaier, Matthias (Author) , Ibrahim, Eman (Author) , Wang, Lei (Author) , Kleist, Christian (Author) , Opelz, Gerhard (Author) , Süsal, Caner (Author) , Ponath, Gerald (Author) , Aly, Mostafa Gaafa (Author) , Alvarez, Cristiam M. (Author) , Kälble, Florian (Author) , Speer, Claudius (Author) , Benning, Louise (Author) , Nußhag, Christian (Author) , Silva, Luiza Pego da (Author) , Sommerer, Claudia (Author) , Hückelhoven-Krauss, Angela (Author) , Czock, David (Author) , Mehrabi, Arianeb (Author) , Schwab, Constantin (Author) , Waldherr, Rüdiger (Author) , Schnitzler, Paul (Author) , Merle, Uta (Author) , Tran, Thuong Hien (Author) , Scherer, Sabine (Author) , Böhmig, Georg A. (Author) , Müller-Tidow, Carsten (Author) , Reiser, Jochen (Author) , Zeier, Martin (Author) , Schmitt, Michael (Author) , Terness, Peter (Author) , Schmitt, Anita (Author) , Daniel, Volker (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Journal of the American Society of Nephrology
Year: 2023, Volume: 34, Issue: 1, Pages: 160-174
ISSN:1533-3450
DOI:10.1681/ASN.2022020210
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1681/ASN.2022020210
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/jasn/Fulltext/2023/01000/Induction_of_Long_Lasting_Regulatory_B_Lymphocytes.18.aspx
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Author Notes:Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Süsal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kälble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hückelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Rüdiger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Böhmig, Carsten Müller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, and Volker Daniel
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Summary:In previous work, the authors demonstrated that kidney transplant recipients developed donor-specific unresponsiveness when they were given a pretransplant infusion of modified donor-derived PBMCs. In this study, they provide evidence that the immunosuppressive properties of these cells persist and the donor-specific unresponsiveness is long-lasting. ...
Item Description:Online veröffentlicht am 22. September 2022
Gesehen am 28.11.2023
Physical Description:Online Resource
ISSN:1533-3450
DOI:10.1681/ASN.2022020210

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