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Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study

Background Whole-genome sequencing (WGS) of Mycobacterium tuberculosis complex has become an important tool in diagnosis and management of drug-resistant tuberculosis. However, data correlating resistance genotype with quantitative phenotypic antimicrobial susceptibility testing (AST) are scarce.

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Bibliographic Details
Main Authors: Finci, Iris (Author) , Albertini, Audrey (Author) , Merker, Matthias (Author) , Andres, Sönke (Author) , Bablishvili, Nino (Author) , Barilar, Ivan (Author) , Cáceres, Tatiana (Author) , Crudu, Valeriu (Author) , Gotuzzo, Eduardo (Author) , Hapeela, Nchimunya (Author) , Hoffmann, Harald (Author) , Hoogland, Christine (Author) , Kohl, Thomas A. (Author) , Kranzer, Katharina (Author) , Mantsoki, Anna (Author) , Maurer, Florian Peter (Author) , Nicol, Mark P. (Author) , Noroc, Ecaterina (Author) , Plesnik, Sara (Author) , Rodwell, Timothy (Author) , Ruhwald, Morten (Author) , Savidge, Theresa (Author) , Salfinger, Max (Author) , Streicher, Elizabeth (Author) , Tukvadze, Nestani (Author) , Warren, Robin (Author) , Zemanay, Widaad (Author) , Zurek, Anna (Author) , Niemann, Stefan (Author) , Denkinger, Claudia M. (Author)
Format: Article (Journal)
Language:English
Published: September 1, 2022
In: The lancet. Microbe
Year: 2022, Volume: 3, Issue: 9, Pages: e672-e682
ISSN:2666-5247
DOI:10.1016/S2666-5247(22)00116-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S2666-5247(22)00116-1
Verlag, lizenzpflichtig, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S2666524722001161
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Author Notes:Iris Finci, Audrey Albertini, Matthias Merker, Sönke Andres, Nino Bablishvili, Ivan Barilar, Tatiana Cáceres, Valeriu Crudu, Eduardo Gotuzzo, Nchimunya Hapeela, Harald Hoffmann, Christine Hoogland, Thomas A. Kohl, Katharina Kranzer, Anna Mantsoki, Florian P. Maurer, Mark P. Nicol, Ecaterina Noroc, Sara Plesnik, Timothy Rodwell, Morten Ruhwald, Theresa Savidge, Max Salfinger, Elizabeth Streicher, Nestani Tukvadze, Robin Warren, Widaad Zemanay, Anna Zurek, Stefan Niemann, Claudia M. Denkinger
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Summary:Background Whole-genome sequencing (WGS) of Mycobacterium tuberculosis complex has become an important tool in diagnosis and management of drug-resistant tuberculosis. However, data correlating resistance genotype with quantitative phenotypic antimicrobial susceptibility testing (AST) are scarce.
Item Description:Online verfügbar: 27. July 22, Artikelversion: 1. September 2022
Gesehen am 20.03.2023
Physical Description:Online Resource
ISSN:2666-5247
DOI:10.1016/S2666-5247(22)00116-1

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