An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line
The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an...
Gespeichert in:
| 1. Verfasser: | |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 September 2010
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| In: |
Virchows Archiv
Year: 2010, Jahrgang: 457, Heft: 5, Pages: 585-595 |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-010-0970-0 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-010-0970-0 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00428-010-0970-0 
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| Verfasserangaben: | Patricia Kohlhof |
MARC
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| 246 | 3 | 3 | |a An additional long-term mechanism of NF-kappaB regulation after cytokine treatment in a human hepatoma cell line |
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| 520 | |a The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an increase in total intracellular NF-κB protein and mRNA levels as well as a temporary colocalization of NF-κB with proteasomes in human hepatocytes after treatment with TNF-α or IL-1β is reported. This indicates that beside an instantaneous activation of NF-κB and partly autoregulated inactivation by breakdown and synthesis of the inhibitors of NF-κB (IκBs), there are also mechanisms for a long-term regulation by de novo-synthesis and degradation of NF-κB protein. | ||
| 650 | 4 | |a HepG2 cells | |
| 650 | 4 | |a IL-1β | |
| 650 | 4 | |a Inflammatory cytokines | |
| 650 | 4 | |a NF-κB degradation | |
| 650 | 4 | |a NF-κB regulation | |
| 650 | 4 | |a NF-κB synthesis | |
| 650 | 4 | |a Proteasomal degradation | |
| 650 | 4 | |a TNF-α | |
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