Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle r...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 Jul 2010
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| In: |
Stem Cells and Development
Year: 2010, Volume: 19, Issue: 11, Pages: 1663-1678 |
| ISSN: | 1557-8534 |
| DOI: | 10.1089/scd.2010.0136 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1089/scd.2010.0136 Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/scd.2010.0136 
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| Author Notes: | Zuzana Koledova, Alwin Krämer, Leona Raskova Kafkova, Vladimir Divoky |
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| 520 | |a Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette. | ||
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