Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-specific transcription factors. However, the mechanisms that induce and maintain appropriate lineage-specific gene expression remain elusive. Here, we used an unbiased proteomics approach to character...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 December 2022
|
| In: |
Molecular cell
Year: 2022, Jahrgang: 82, Heft: 24, Pages: 4627-4646, e1-e14 |
| ISSN: | 1097-4164 |
| DOI: | 10.1016/j.molcel.2022.11.002 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molcel.2022.11.002 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1097276522010644 
|
| Verfasserangaben: | Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, and Marius Wernig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1839748060 | ||
| 003 | DE-627 | ||
| 005 | 20231122134207.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230322s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molcel.2022.11.002 |2 doi | |
| 035 | |a (DE-627)1839748060 | ||
| 035 | |a (DE-599)KXP1839748060 | ||
| 035 | |a (OCoLC)1389534281 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Janas, Justyna |e VerfasserIn |0 (DE-588)1310767475 |0 (DE-627)1870880412 |4 aut | |
| 245 | 1 | 0 | |a Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation |c Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, and Marius Wernig |
| 246 | 3 | 0 | |a Tip60 - mediated H2A . Z |
| 264 | 1 | |c 15 December 2022 | |
| 300 | |b Illustrationen | ||
| 300 | |a 34 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlich am 22. November 2022 | ||
| 500 | |a Gesehen am 22.11.2023 | ||
| 520 | |a Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-specific transcription factors. However, the mechanisms that induce and maintain appropriate lineage-specific gene expression remain elusive. Here, we used an unbiased proteomics approach to characterize chromatin regulators that mediate the induction of neuronal cell fate. We found that Tip60 acetyltransferase is essential to establish neuronal cell identity partly via acetylation of the histone variant H2A.Z. Despite its tight correlation with gene expression and active chromatin, loss of H2A.Z acetylation had little effect on chromatin accessibility or transcription. Instead, loss of Tip60 and acetyl-H2A.Z interfered with H3K4me3 deposition and activation of a unique subset of silent, lineage-restricted genes characterized by a bivalent chromatin configuration at their promoters. Altogether, our results illuminate the mechanisms underlying bivalent chromatin activation and reveal that H2A.Z acetylation regulates neuronal fate specification by establishing epigenetic competence for bivalent gene activation and cell lineage transition. | ||
| 650 | 4 | |a Ascl1 | |
| 650 | 4 | |a bivalent chromatin | |
| 650 | 4 | |a cell fate | |
| 650 | 4 | |a gene activation | |
| 650 | 4 | |a H2A.Z acetylation | |
| 650 | 4 | |a H3K4me3 | |
| 650 | 4 | |a neurogenesis | |
| 650 | 4 | |a reprogramming | |
| 650 | 4 | |a Tip60/Kat5 | |
| 650 | 4 | |a transcription | |
| 700 | 1 | |a Zhang, Lichao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luu, Jacklyn H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Demeter, Janos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meng, Lingjun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marro, Samuele G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mall, Moritz |e VerfasserIn |0 (DE-588)1168277477 |0 (DE-627)1031930213 |0 (DE-576)511500866 |4 aut | |
| 700 | 1 | |a Mooney, Nancie A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaukowitch, Katie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ng, Yi Han |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yang, Nan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Yuhao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neumayer, Gernot |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gozani, Or |e VerfasserIn |4 aut | |
| 700 | 1 | |a Elias, Joshua E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jackson, Peter K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wernig, Marius |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular cell |d [Cambridge, Mass.] : Cell Press, 1997 |g 82(2022), 24, Seite 4627-4646, e1-e14 |h Online-Ressource |w (DE-627)320416097 |w (DE-600)2001948-8 |w (DE-576)090881362 |x 1097-4164 |7 nnas |a Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation |
| 773 | 1 | 8 | |g volume:82 |g year:2022 |g number:24 |g pages:4627-4646, e1-e14 |g extent:34 |a Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.molcel.2022.11.002 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1097276522010644 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230322 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1168277477 |a Mall, Moritz |m 1168277477:Mall, Moritz |d 140000 |e 140000PM1168277477 |k 0/140000/ |p 7 | ||
| 999 | |a KXP-PPN1839748060 |e 4294479639 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"15 December 2022","dateIssuedKey":"2022"}],"recId":"1839748060","name":{"displayForm":["Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, and Marius Wernig"]},"physDesc":[{"extent":"34 S.","noteIll":"Illustrationen"}],"id":{"doi":["10.1016/j.molcel.2022.11.002"],"eki":["1839748060"]},"language":["eng"],"relHost":[{"part":{"volume":"82","extent":"34","pages":"4627-4646, e1-e14","issue":"24","text":"82(2022), 24, Seite 4627-4646, e1-e14","year":"2022"},"pubHistory":["1.1997/98 -"],"origin":[{"dateIssuedKey":"1997","publisher":"Cell Press ; Elsevier","dateIssuedDisp":"1997-","publisherPlace":"[Cambridge, Mass.] ; New York, NY"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"320416097","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1097-4164"],"zdb":["2001948-8"],"eki":["320416097"]},"disp":"Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activationMolecular cell","language":["eng"],"note":["Gesehen am 01.08.25"],"title":[{"title_sort":"Molecular cell","title":"Molecular cell"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Justyna","family":"Janas","display":"Janas, Justyna"},{"display":"Zhang, Lichao","family":"Zhang","given":"Lichao","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Luu, Jacklyn H.","family":"Luu","given":"Jacklyn H.","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Janos","roleDisplay":"VerfasserIn","role":"aut","display":"Demeter, Janos","family":"Demeter"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Lingjun","family":"Meng","display":"Meng, Lingjun"},{"family":"Marro","display":"Marro, Samuele G.","roleDisplay":"VerfasserIn","role":"aut","given":"Samuele G."},{"family":"Mall","display":"Mall, Moritz","role":"aut","roleDisplay":"VerfasserIn","given":"Moritz"},{"family":"Mooney","display":"Mooney, Nancie A.","role":"aut","roleDisplay":"VerfasserIn","given":"Nancie A."},{"given":"Katie","roleDisplay":"VerfasserIn","role":"aut","display":"Schaukowitch, Katie","family":"Schaukowitch"},{"display":"Ng, Yi Han","family":"Ng","given":"Yi Han","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Nan","family":"Yang","display":"Yang, Nan"},{"family":"Huang","display":"Huang, Yuhao","role":"aut","roleDisplay":"VerfasserIn","given":"Yuhao"},{"family":"Neumayer","display":"Neumayer, Gernot","role":"aut","roleDisplay":"VerfasserIn","given":"Gernot"},{"display":"Gozani, Or","family":"Gozani","given":"Or","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Elias, Joshua E.","family":"Elias","given":"Joshua E.","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Peter K.","family":"Jackson","display":"Jackson, Peter K."},{"given":"Marius","role":"aut","roleDisplay":"VerfasserIn","display":"Wernig, Marius","family":"Wernig"}],"note":["Online veröffentlich am 22. November 2022","Gesehen am 22.11.2023"],"title":[{"title":"Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation","title_sort":"Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation"}]} | ||
| SRT | |a JANASJUSTYTIP60MEDIA1520 | ||