The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions
Fibrotic changes in the myocardium and cardiac arrhythmias represent fatal complications in systemic sclerosis (SSc), however the underlying mechanisms remain elusive. Mice overexpressing transcription factor Fosl-2 (Fosl-2tg) represent animal model of SSc. Fosl-2tg mice showed interstitial cardiac...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 February 2023
|
| In: |
Communications biology
Year: 2023, Jahrgang: 6, Pages: 1-15 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-023-04534-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42003-023-04534-6 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42003-023-04534-6 
|
| Verfasserangaben: | Mara Stellato, Matthias Dewenter, Michal Rudnik, Amela Hukara, Çagla Özsoy, Florian Renoux, Elena Pachera, Felix Gantenbein, Petra Seebeck, Siim Uhtjaerv, Elena Osto, Daniel Razansky, Karin Klingel, Joerg Henes, Oliver Distler, Przemysław Błyszczuk & Gabriela Kania |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1839762713 | ||
| 003 | DE-627 | ||
| 005 | 20230706215558.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230322s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s42003-023-04534-6 |2 doi | |
| 035 | |a (DE-627)1839762713 | ||
| 035 | |a (DE-599)KXP1839762713 | ||
| 035 | |a (OCoLC)1389531107 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stellato, Mara |e VerfasserIn |0 (DE-588)1284084221 |0 (DE-627)1839763167 |4 aut | |
| 245 | 1 | 4 | |a The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions |c Mara Stellato, Matthias Dewenter, Michal Rudnik, Amela Hukara, Çagla Özsoy, Florian Renoux, Elena Pachera, Felix Gantenbein, Petra Seebeck, Siim Uhtjaerv, Elena Osto, Daniel Razansky, Karin Klingel, Joerg Henes, Oliver Distler, Przemysław Błyszczuk & Gabriela Kania |
| 246 | 3 | 0 | |a one two |
| 264 | 1 | |c 09 February 2023 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.03.2023 | ||
| 520 | |a Fibrotic changes in the myocardium and cardiac arrhythmias represent fatal complications in systemic sclerosis (SSc), however the underlying mechanisms remain elusive. Mice overexpressing transcription factor Fosl-2 (Fosl-2tg) represent animal model of SSc. Fosl-2tg mice showed interstitial cardiac fibrosis, disorganized connexin-43/40 in intercalated discs and deregulated expression of genes controlling conduction system, and developed higher heart rate (HR), prolonged QT intervals, arrhythmias with prevalence of premature ventricular contractions, ventricular tachycardias, II-degree atrio-ventricular blocks and reduced HR variability. Following stimulation with isoproterenol Fosl-2tg mice showed impaired HR response. In contrast to Fosl-2tg, immunodeficient Rag2−/−Fosl-2tg mice were protected from enhanced myocardial fibrosis and ECG abnormalities. Transcriptomics analysis demonstrated that Fosl-2-overexpression was responsible for profibrotic signature of cardiac fibroblasts, whereas inflammatory component in Fosl-2tg mice activated their fibrotic and arrhythmogenic phenotype. In human cardiac fibroblasts FOSL-2-overexpression enhanced myofibroblast signature under proinflammatory or profibrotic stimuli. These results demonstrate that under immunofibrotic conditions transcription factor Fosl-2 exaggerates myocardial fibrosis, arrhythmias and aberrant response to stress. | ||
| 650 | 4 | |a Cell biology | |
| 650 | 4 | |a Rheumatic diseases | |
| 700 | 1 | |a Dewenter, Matthias |e VerfasserIn |0 (DE-588)1148565558 |0 (DE-627)1008763721 |0 (DE-576)496327763 |4 aut | |
| 700 | 1 | |a Rudnik, Michal |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hukara, Amela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Özsoy, Çagla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Renoux, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pachera, Elena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gantenbein, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seebeck, Petra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Uhtjaerv, Siim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Osto, Elena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Razansky, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klingel, Karin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henes, Joerg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Distler, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Błyszczuk, Przemysław |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kania, Gabriela |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Communications biology |d London : Springer Nature, 2018 |g 6(2023) vom: Feb., Artikel-ID 161, Seite 1-15 |h Online-Ressource |w (DE-627)101369080X |w (DE-600)2919698-X |w (DE-576)499739132 |x 2399-3642 |7 nnas |a The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions |
| 773 | 1 | 8 | |g volume:6 |g year:2023 |g month:02 |g elocationid:161 |g pages:1-15 |g extent:15 |a The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s42003-023-04534-6 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s42003-023-04534-6 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230322 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1148565558 |a Dewenter, Matthias |m 1148565558:Dewenter, Matthias |d 910000 |d 910100 |e 910000PD1148565558 |e 910100PD1148565558 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 999 | |a KXP-PPN1839762713 |e 4294568666 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 22.03.2023"],"person":[{"family":"Stellato","given":"Mara","display":"Stellato, Mara","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Dewenter","given":"Matthias","display":"Dewenter, Matthias","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Rudnik","given":"Michal","roleDisplay":"VerfasserIn","role":"aut","display":"Rudnik, Michal"},{"display":"Hukara, Amela","role":"aut","roleDisplay":"VerfasserIn","family":"Hukara","given":"Amela"},{"given":"Çagla","family":"Özsoy","display":"Özsoy, Çagla","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Renoux","given":"Florian","roleDisplay":"VerfasserIn","role":"aut","display":"Renoux, Florian"},{"given":"Elena","family":"Pachera","roleDisplay":"VerfasserIn","role":"aut","display":"Pachera, Elena"},{"given":"Felix","family":"Gantenbein","display":"Gantenbein, Felix","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Seebeck, Petra","role":"aut","roleDisplay":"VerfasserIn","given":"Petra","family":"Seebeck"},{"given":"Siim","family":"Uhtjaerv","role":"aut","roleDisplay":"VerfasserIn","display":"Uhtjaerv, Siim"},{"display":"Osto, Elena","role":"aut","roleDisplay":"VerfasserIn","given":"Elena","family":"Osto"},{"display":"Razansky, Daniel","role":"aut","roleDisplay":"VerfasserIn","family":"Razansky","given":"Daniel"},{"display":"Klingel, Karin","role":"aut","roleDisplay":"VerfasserIn","family":"Klingel","given":"Karin"},{"display":"Henes, Joerg","role":"aut","roleDisplay":"VerfasserIn","family":"Henes","given":"Joerg"},{"family":"Distler","given":"Oliver","role":"aut","roleDisplay":"VerfasserIn","display":"Distler, Oliver"},{"display":"Błyszczuk, Przemysław","roleDisplay":"VerfasserIn","role":"aut","given":"Przemysław","family":"Błyszczuk"},{"given":"Gabriela","family":"Kania","roleDisplay":"VerfasserIn","role":"aut","display":"Kania, Gabriela"}],"physDesc":[{"extent":"15 S."}],"recId":"1839762713","language":["eng"],"relHost":[{"origin":[{"dateIssuedDisp":"[2018]-","publisher":"Springer Nature","publisherPlace":"London"}],"part":{"text":"6(2023) vom: Feb., Artikel-ID 161, Seite 1-15","pages":"1-15","volume":"6","extent":"15","year":"2023"},"id":{"zdb":["2919698-X"],"eki":["101369080X"],"issn":["2399-3642"]},"recId":"101369080X","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditionsCommunications biology","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1 (2018)-"],"title":[{"title":"Communications biology","title_sort":"Communications biology"}]}],"id":{"eki":["1839762713"],"doi":["10.1038/s42003-023-04534-6"]},"origin":[{"dateIssuedDisp":"09 February 2023","dateIssuedKey":"2023"}],"name":{"displayForm":["Mara Stellato, Matthias Dewenter, Michal Rudnik, Amela Hukara, Çagla Özsoy, Florian Renoux, Elena Pachera, Felix Gantenbein, Petra Seebeck, Siim Uhtjaerv, Elena Osto, Daniel Razansky, Karin Klingel, Joerg Henes, Oliver Distler, Przemysław Błyszczuk & Gabriela Kania"]},"title":[{"title_sort":"AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions","title":"The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a STELLATOMAAP1TRANSCR0920 | ||