Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group
Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To analyze the impact of therapy-related hyperbilirubinemia on treatment outcome and to identify cont...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 January 2023
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| In: |
Journal of experimental & clinical cancer research
Year: 2023, Jahrgang: 42, Pages: 1-15 |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/s13046-022-02585-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13046-022-02585-x
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| Verfasserangaben: | Stefanie V. Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina U. Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian P. Kratz, Martin Schrappe, Matthias Schwab, Richard S. Houlston, Gunnar Cario and Martin Stanulla |
MARC
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| 520 | |a Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To analyze the impact of therapy-related hyperbilirubinemia on treatment outcome and to identify contributing genetic risk factors of this well-recognized adverse effect we evaluated serum bilirubin levels in 1547 pediatric patients with acute lymphoblastic leukemia (ALL) and conducted a genome-wide association study (GWAS). | ||
| 650 | 4 | |a Childhood acute lymphoblastic leukemia | |
| 650 | 4 | |a Hepatotoxicity | |
| 650 | 4 | |a Hyperbilirubinemia | |
| 650 | 4 | |a Treatment-related toxicity | |
| 650 | 4 | |a UGT1A | |
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