Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex
Abstract Cells dynamically adapt organelle size to current physiological demand. Organelle growth requires membrane biogenesis and therefore needs to be coordinated with lipid metabolism. The endoplasmic reticulum (ER) can undergo massive expansion, but the underlying regulatory mechanisms are large...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
The EMBO journal
Year: 2021, Jahrgang: 40, Heft: 22, Pages: 1-23 |
| ISSN: | 1460-2075 |
| DOI: | 10.15252/embj.2021107958 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.15252/embj.2021107958 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/embj.2021107958 
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| Verfasserangaben: | Dimitrios Papagiannidis, Peter W Bircham, Christian Lüchtenborg, Oliver Pajonk, Giulia Ruffini, Britta Brügger & Sebastian Schuck |
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| 520 | |a Abstract Cells dynamically adapt organelle size to current physiological demand. Organelle growth requires membrane biogenesis and therefore needs to be coordinated with lipid metabolism. The endoplasmic reticulum (ER) can undergo massive expansion, but the underlying regulatory mechanisms are largely unclear. Here, we describe a genetic screen for factors involved in ER membrane expansion in budding yeast and identify the ER transmembrane protein Ice2 as a strong hit. We show that Ice2 promotes ER membrane biogenesis by opposing the phosphatidic acid phosphatase Pah1, called lipin in metazoa. Specifically, Ice2 inhibits the conserved Nem1-Spo7 complex and thus suppresses the dephosphorylation and activation of Pah1. Furthermore, Ice2 cooperates with the transcriptional regulation of lipid synthesis genes and helps to maintain cell homeostasis during ER stress. These findings establish the control of the lipin phosphatase complex as an important mechanism for regulating ER membrane biogenesis. | ||
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